Department of Medicine, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA.
Division of Abdominal Organ Transplantation and HPB Surgery, School of Medicine, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA.
Clin Liver Dis. 2021 Feb;25(1):137-155. doi: 10.1016/j.cld.2020.08.012.
Hepatitis C virus has historically been the leading indication for liver transplant, followed by nonalcoholic steatohepatitis (NASH) and alcoholic liver disease. Severe alcoholic hepatitis has become a growing indication for liver transplant, and overall alcohol use rates continue to increase in the United States. Rates of obesity and NASH in the United States continue to increase and are expected to place increasing demand on liver transplant infrastructure. In the current absence of robust pharmacologic therapy for NASH, the use of bariatric procedures and surgeries is being explored, as are other innovative approaches to curtail this upward trend.
丙型肝炎病毒一直是肝移植的主要适应证，其次是非酒精性脂肪性肝炎（NASH）和酒精性肝病。严重酒精性肝炎已成为肝移植的一个日益增长的适应证，而且美国的总体酒精使用率仍在持续上升。美国的肥胖和 NASH 发生率持续上升，预计这将增加对肝移植基础设施的需求。在目前缺乏针对 NASH 的有效药物治疗的情况下，正在探索使用减重手术和其他手术，以及其他创新方法来遏制这一上升趋势。
