School of Kinesiology, Shenyang Sport University, Shenyang, China.
J Diabetes Investig. 2021 Aug;12(8):1306-1315. doi: 10.1111/jdi.13571. Epub 2021 Jun 3.
Obesity is a serious health issue in the world and is related to a higher risk of suffering metabolic diseases. Understanding the molecular basis of obesity is critical to identify new targets to treat obesity and obesity-associated metabolic diseases. N6-methyladenosine (m6A) modification is the most common form of ribonucleic acid modification, which has attracted increasing interest of researchers in recent years, as it is reported that m6A has vital functions in diseases and everyday life activities. Recent studies showed that m6A modification was decreased in obese adipose tissue, and appeared to play a regulatory role in many obesity-associated biological processes, including adipogenesis, lipid metabolism and insulin resistance. In this review, we discussed the emerging advances in m6A modification in obesity to provide a novel therapeutic strategy for fighting against obesity.
肥胖是全球范围内一个严重的健康问题，与代谢性疾病的风险增加有关。了解肥胖的分子基础对于确定新的靶点来治疗肥胖和肥胖相关的代谢性疾病至关重要。N6-甲基腺苷（m6A）修饰是最常见的 RNA 修饰形式，近年来引起了研究人员越来越多的关注，因为据报道 m6A 在疾病和日常生活活动中具有重要功能。最近的研究表明，肥胖脂肪组织中的 m6A 修饰减少，并且似乎在许多与肥胖相关的生物学过程中发挥调节作用，包括脂肪生成、脂质代谢和胰岛素抵抗。在这篇综述中，我们讨论了 m6A 修饰在肥胖中的新进展，为对抗肥胖提供了一种新的治疗策略。
