School of Technology and Management, Polytechnic Institute of Leiria, Morro do Lena, Alto do Vieiro, 2411-901, Leiria, Portugal.
School of Technology and Management, Polytechnic Institute of Leiria, Morro do Lena, Alto do Vieiro, 2411-901, Leiria, Portugal.
Environ Toxicol Pharmacol. 2021 Aug;86:103671. doi: 10.1016/j.etap.2021.103671. Epub 2021 May 9.
Human exposure to polycyclic aromatic hydrocarbons (PAHs) and organophosphorus pesticides (OPPs) by dermal route is a continuing concern in environmental and occupational toxicology. Diverse authors have measured in vitro the absorption flux and permeability coefficient (k) of those compounds delivered on skin surface using volatile solvents. However, there isn't a harmonized method to obtain k when the test substance is deposited on the skin as a solid. Consequently, varied experimental ks have been reported for PAHs and OPPs, most in clear disagreement with the values predicted by well-established mathematical models. In this work, we collected the permeation fluxes reported for these toxicants through human skin and calculated the (aqueous) ks using a method based on the maximum flux and water solubility. The reanalyzed fluxes and recalculated ks show improved consistency between the different experimental works and mathematical models. Notably, the recalculated k of benzo[a]pyrene, among others, was approximately 100 times higher than it had been previously considered. Suggestions are given to generalize the method in studies with other solvent-deposited toxicants and drugs.
人体通过皮肤接触多环芳烃（PAHs）和有机磷农药（OPPs）是环境毒理学和职业毒理学中持续关注的问题。许多作者已经测量了在体外使用挥发性溶剂在皮肤表面上输送的这些化合物的吸收通量和渗透系数（k）。然而，当测试物质作为固体沉积在皮肤上时，并没有获得 k 的统一方法。因此，已经报道了 PAHs 和 OPPs 的各种实验 k 值，大多数与经过良好验证的数学模型预测的值明显不一致。在这项工作中，我们收集了这些有毒物质通过人体皮肤的渗透通量报告，并使用基于最大通量和水溶解度的方法计算了（水相）k 值。重新分析的通量和重新计算的 k 值显示了不同实验工作和数学模型之间的一致性得到了改善。值得注意的是，重新计算的苯并[a]芘等的 k 值比以前认为的要高约 100 倍。建议将该方法推广到其他溶剂沉积毒物和药物的研究中。
