Pidd J G, Gardner D L, Adams M E
Department of Histopathology, Victoria University of Manchester, UK.
J Rheumatol. 1988 Apr;15(4):663-9.
Skeletally mature male American foxhounds were subjected to surgical transection of the right anterior cruciate ligament; they developed osteoarthritis of this stifle joint. The results were compared with joints from sham operated and nonoperated controls. Articular cartilage from each lateral femoral condyle was viewed by transmission electron microscopy. The ultrastructure of control and of experimental tissues was compared with that of similar, previous studies made in beagles. Both forms of foxhound control tissue were indistinguishable from normal beagle femoral condylar cartilage. Ultrastructural changes observed in the foxhound up to 16 weeks after cruciate ligament surgery were closely similar to those recorded in the beagle; they included alterations of chondrocyte morphology and the deposition of an electron dense cartilage surface coat. However, the degree of cartilage disorganization after 64 weeks was greater than, and qualitatively distinct from, that observed in the beagle.
骨骼成熟的雄性美国猎狐犬接受了右前交叉韧带的手术横断；它们发展出了该膝关节的骨关节炎。将结果与假手术对照组和未手术对照组的关节进行比较。通过透射电子显微镜观察每个外侧股骨髁的关节软骨。将对照组织和实验组织的超微结构与之前在比格犬身上进行的类似研究进行比较。两种形式的猎狐犬对照组织与正常比格犬股骨髁软骨无法区分。在猎狐犬交叉韧带手术后长达16周观察到的超微结构变化与在比格犬中记录的变化非常相似；它们包括软骨细胞形态的改变以及电子致密软骨表面涂层的沉积。然而，64周后软骨的紊乱程度大于在比格犬中观察到的程度，并且在性质上有所不同。
