Llewellyn J G, Pritchard M H
Department of Rheumatology, University Hospital of Wales, Heath Park, Cardiff, UK.
J Rheumatol. 1988 Apr;15(4):691-4.
In our study of 552 acute admissions for gastrointestinal hemorrhage, 18% were found to be taking nonsteroidal antiinflammatory drugs (NSAID) at the time of the bleed; 49% of these were found at endoscopy to have a gastric or prepyloric lesion, compared with 20% of the non-NSAID control group. Prescription data was used to calculate the risk added by age and disease state to the NSAID associated bleeding. We found that patients with chronic inflammatory disease had 2-3 times the expected bleeding incidence, but while there was a definite trend towards an age related risk in older patients, this was not statistically significant.
在我们对552例急性胃肠道出血入院病例的研究中，发现18%的患者在出血时正在服用非甾体抗炎药（NSAID）；在内镜检查中，这些患者中有49%存在胃或幽门前病变，而非NSAID对照组的这一比例为20%。利用处方数据计算年龄和疾病状态给NSAID相关出血增加的风险。我们发现，患有慢性炎症性疾病的患者出血发生率是预期的2至3倍，然而，虽然老年患者存在与年龄相关风险的明确趋势，但这在统计学上并不显著。
