Interfaculty Institute of Microbiology and Infection Medicine Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany.
Microb Physiol. 2021;31(2):67-77. doi: 10.1159/000515617. Epub 2021 May 12.
Polyhydroxybutyrate (PHB) is a carbon polymer with diverse functions, varying greatly on the organism producing it. This microreview describes the current knowledge about PHB metabolism, structure, and different physiological roles with a special focus on cyanobacteria. Despite the physiological function of PHB in the cyanobacterial phylum still being unknown, these organisms provide the unique opportunity to directly convert atmospheric CO2 into bioplastic using a solar-based process. Recent research on PHB metabolism in the cyanobacterial model organism Synechocystis revealed a sophisticated control of PHB granule formation. Novel insights about the metabolic background of PHB synthesis resulted in the engineering of the first cyanobacterial superproducer strain.
聚羟基丁酸酯（PHB）是一种具有多种功能的碳聚合物，其功能因产生它的生物体而异。这篇微型综述描述了目前关于 PHB 代谢、结构和不同生理作用的知识，特别关注蓝细菌。尽管 PHB 在蓝细菌门中的生理功能尚不清楚，但这些生物体提供了独特的机会，可以使用基于太阳能的工艺将大气中的 CO2 直接转化为生物塑料。最近对蓝细菌模式生物集胞藻的 PHB 代谢的研究揭示了 PHB 颗粒形成的精细控制。对 PHB 合成代谢背景的新认识导致了第一个蓝细菌超级生产菌株的工程设计。
