Martínez María de Los Ángeles Martínez, Urzúa Lucía Soto, Carrillo Yovani Aguilar, Ramírez Mirian Becerril, Morales Luis Javier Martínez
Centro de Investigaciones en Ciencias Microbiológicas, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Av. San Claudio y Av. 24 Sur, Col. San Manuel Ciudad Universitaria, Puebla 72570, Mexico.
Polymers (Basel). 2023 Jul 13;15(14):3027. doi: 10.3390/polym15143027.
Gram-negative accumulates approximately 80% of polyhydroxybutyrate (PHB) as dry cell weight. For this reason, this bacterium has been characterized as one of the main microorganisms that produce PHB. PHB is synthesized inside bacteria by the polymerization of 3-hydroxybutyrate monomers. In this review, we are focusing on the analysis of the PHB production by in order to understand the metabolism during PHB accumulation. First, the carbon and nitrogen sources used to improve PHB accumulation are discussed. accumulates more PHB when it is grown on a minimal medium containing a high C/N ratio, mainly from malate and ammonia chloride, respectively. The metabolic pathways to accumulate and mobilize PHB in are mentioned and compared with those of other microorganisms. Next, we summarize the available information to understand the role of the genes involved in the regulation of PHB metabolism as well as the role of PHB in the physiology of . Finally, we made a comparison between the properties of PHB and polypropylene, and we discussed some applications of PHB in biomedical and commercial areas.
革兰氏阴性菌积累的聚羟基丁酸酯（PHB）约占干细胞重量的80%。因此，这种细菌被认为是产生PHB的主要微生物之一。PHB是由3-羟基丁酸单体在细菌内聚合而成。在本综述中，我们重点分析了[细菌名称未给出]产生PHB的情况，以便了解PHB积累过程中的代谢情况。首先，讨论了用于提高PHB积累的碳源和氮源。当[细菌名称未给出]在含有高碳氮比的基本培养基上生长时，积累的PHB更多，碳源主要来自苹果酸，氮源主要来自氯化铵。文中提到了[细菌名称未给出]中积累和动员PHB的代谢途径，并与其他微生物的进行了比较。接下来，我们总结了现有信息，以了解参与PHB代谢调控的基因的作用以及PHB在[细菌名称未给出]生理学中的作用。最后，我们比较了PHB和聚丙烯的特性，并讨论了PHB在生物医学和商业领域的一些应用。
