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听觉言语幻觉与精神病连续谱中的儿童期创伤亚型:聚类分析。

Auditory verbal hallucinations and childhood trauma subtypes across the psychosis continuum: a cluster analysis.

机构信息

Department of Biomedical Sciences of Cells & Systems, Section Cognitive Neurosciences, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

School of Health and Behavioural Sciences, University of the Sunshine Coast, Sippy Downs, Australia.

出版信息

Cogn Neuropsychiatry. 2022 Mar-May;27(2-3):150-168. doi: 10.1080/13546805.2021.1925235. Epub 2021 May 13.

DOI:10.1080/13546805.2021.1925235
PMID:33980128
Abstract

A strong link between voice-hearing experience and childhood trauma has been established. The aim of this study was to identify whether there were unique clusters of childhood trauma subtypes in a sample across the clinical spectrum of auditory verbal hallucinations (AVH) and to examine clinical and phenomenological features across these clusters. Combining two independent international datasets (the Netherlands and Australia), childhood trauma subtypes were examined using hierarchical cluster analysis. Clinical and phenomenological characteristics were compared across emerging clusters using MANOVA and chi-squared analyses. The total sample ( = 413) included 166 clinical individuals with a psychotic disorder and AVH, 122 non-clinical individuals with AVH and 125 non-clinical individuals without AVH. Three clusters emerged: (1) low trauma ( = 299); (2) emotion-focused trauma ( = 71); (3) multi-trauma ( = 43). The three clusters differed significantly on their AVH ratings of amount of negative content, with trend-level effects for loudness, degree of negative content and degree of experienced distress. Furthermore, perceptions of voices being malevolent, benevolent and resistance towards voices differed significantly. The data revealed different types of childhood trauma had different relationships between clinical and phenomenological features of voice-hearing experiences. Thus, implicating different mechanistic pathways and a need for tailored treatment approaches.

摘要

已证实,幻听体验与童年创伤之间存在紧密联系。本研究旨在确定在听觉言语幻觉(AVH)的临床谱系范围内的样本中是否存在具有独特特征的童年创伤亚群,并研究这些亚群的临床和现象学特征。通过层次聚类分析,结合两个独立的国际数据集(荷兰和澳大利亚),对童年创伤亚型进行了研究。使用 MANOVA 和卡方分析比较了新兴聚类中的临床和现象学特征。总样本( = 413)包括 166 名患有精神障碍和 AVH 的临床个体,122 名有 AVH 但无临床症状的个体和 125 名无 AVH 的个体。三个聚类出现:(1)低创伤( = 299);(2)情绪聚焦创伤( = 71);(3)多创伤( = 43)。这三个聚类在其 AVH 评分的负性内容量方面存在显著差异,在响度、负性内容程度和体验到的痛苦程度方面存在趋势性影响。此外,对声音的恶意、善意和对声音的抵抗的感知也存在显著差异。数据显示,不同类型的童年创伤与幻听体验的临床和现象学特征之间存在不同的关系。因此,这表明存在不同的机制途径,需要量身定制的治疗方法。

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Hallucinations in the Child and Adolescent "Ultra-High Risk" population: A Systematic Review.儿童和青少年“超高风险”人群中的幻觉:一项系统综述。
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A systematic review and meta-analysis of the traumatogenic phenotype hypothesis of psychosis.
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BJPsych Open. 2024 Aug 9;10(5):e146. doi: 10.1192/bjo.2024.52.
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Cluster analysis exploring the impact of childhood neglect on cognitive function in patients with bipolar disorder.聚类分析探究童年期忽视对双相情感障碍患者认知功能的影响。
Int J Bipolar Disord. 2024 Apr 27;12(1):13. doi: 10.1186/s40345-024-00335-w.
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Investigating Specific Associations Between Childhood Victimization Profiles and Positive Psychosis Symptoms: The Mediating Roles of Anxiety, Depression, and Schema.探究童年期受侵害情况与阳性精神病性症状之间的特定关联:焦虑、抑郁和图式的中介作用
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