Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, Wuhan, 430030, Hubei, China.
BMC Anesthesiol. 2021 May 12;21(1):144. doi: 10.1186/s12871-021-01367-w.
Nebulized lidocaine reduced stress response for endotracheal intubation. However, the impact of novel lidocaine aerosol inhalation for intubation by ultrasonic atomizer was unclear. Hence, we designed aerosol inhalation of lidocaine by ultrasonic atomizer, to seek whether the dosage of sufentanil for intubation could be less or not.
Intravenous injection of sufentanil started at 0.5 μg/kg, and sufentanil dosage was increased/decreased (step-size 0.05 μg/kg for sufentanil) using Dixon's up and down method. The observation was terminated after 8 reflexes.
The EC50 and EC95 of sufentanil with lidocaine by ultrasonic atomizer for intubation were found to be 0.232 μg/kg (95% CI: 0.187-0.270 μg/kg) and 0.447 μg/kg (95% CI: 0.364-0.703 μg/kg). 55.88% out of 34 patients showed hemodynamic index change < 20% of baseline during intubation.
Aerosol inhalation of lidocaine by ultrasonic atomizer reduced the dosage of sufentanil for endotracheal intubation. Lidocaine inhalation by ultrasonic atomizer for airway anesthesia with minimal dosage of sufentanil could be recommended, particularly in patients who need more stable hemodynamic changes or spontaneous respiration.
Chinese Registry of Central Trial, ChiCTR-IOR-17014198 . Registered 28 December 2017.
雾化利多卡因可减轻气管插管的应激反应。然而，超声雾化器吸入新型利多卡因用于插管的影响尚不清楚。因此，我们设计了超声雾化器吸入利多卡因，以探讨是否可以减少舒芬太尼的插管剂量。
静脉注射舒芬太尼起始剂量为 0.5μg/kg，采用 Dixon 上下法递增/递减舒芬太尼剂量（舒芬太尼剂量递增/递减步长为 0.05μg/kg）。观察 8 次反射后结束。
超声雾化器利多卡因用于插管的舒芬太尼 EC50 和 EC95 分别为 0.232μg/kg（95%CI：0.187-0.270μg/kg）和 0.447μg/kg（95%CI：0.364-0.703μg/kg）。34 例患者中有 55.88%在插管过程中血流动力学指数变化<基线的 20%。
超声雾化器利多卡因吸入降低了气管插管的舒芬太尼剂量。超声雾化器吸入利多卡因用于气道麻醉，舒芬太尼最小剂量可能被推荐，特别是在需要更稳定的血流动力学变化或自主呼吸的患者中。
中国临床试验注册中心，ChiCTR-IOR-17014198。注册于 2017 年 12 月 28 日。
