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EAACI position paper: irritant-induced asthma.欧洲变应原学会立场文件:刺激性诱导哮喘。
Allergy. 2014 Sep;69(9):1141-53. doi: 10.1111/all.12448. Epub 2014 Jul 5.
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Which agents cause reactive airways dysfunction syndrome (RADS)? A systematic review.哪些因素会导致反应性气道功能障碍综合征(RADS)?一项系统评价。
Occup Med (Lond). 2008 May;58(3):205-11. doi: 10.1093/occmed/kqn013. Epub 2008 Feb 27.
3
Reactive airways dysfunction syndrome in housewives due to a bleach-hydrochloric acid mixture.家庭主妇因漂白剂 - 盐酸混合物导致的反应性气道功能障碍综合征
Inhal Toxicol. 2004 Feb;16(2):87-91. doi: 10.1080/08958370490265004.
4
Treatment of asthma with nebulized lidocaine: a randomized, placebo-controlled study.雾化利多卡因治疗哮喘:一项随机、安慰剂对照研究。
J Allergy Clin Immunol. 2004 May;113(5):853-9. doi: 10.1016/j.jaci.2004.02.039.
5
Reactive airways dysfunction syndrome (RADS): guidelines for diagnosis and treatment and insight into likely prognosis.反应性气道功能障碍综合征(RADS):诊断与治疗指南及对可能预后的见解
Ann Allergy Asthma Immunol. 1999 Dec;83(6 Pt 2):583-6. doi: 10.1016/S1081-1206(10)62876-1.
6
Nebulized lidocaine in the treatment of severe asthma in children: a pilot study.雾化利多卡因治疗儿童重症哮喘:一项初步研究。
Ann Allergy Asthma Immunol. 1999 Jan;82(1):29-32. doi: 10.1016/S1081-1206(10)62656-7.
7
Seizure after lidocaine for bronchoscopy: case report and review of the use of lidocaine in airway anesthesia.支气管镜检查利多卡因麻醉后癫痫发作:病例报告及气道麻醉中利多卡因使用的综述
Pharmacotherapy. 1993 Jan-Feb;13(1):72-8.
8
Reactive airways dysfunction syndrome (RADS). Persistent asthma syndrome after high level irritant exposures.反应性气道功能障碍综合征(RADS)。高浓度刺激性物质暴露后出现的持续性哮喘综合征。
Chest. 1985 Sep;88(3):376-84. doi: 10.1378/chest.88.3.376.
9
Effects of inhaled lidocaine on airway function in asthmatic subjects.吸入利多卡因对哮喘患者气道功能的影响。
Respiration. 1979;37(4):201-7. doi: 10.1159/000194028.

雾化利多卡因作为反应性气道功能障碍综合征的替代疗法

Nebulized Lidocaine as an Alternative Therapy for Reactive Airway Dysfunction Syndrome.

作者信息

Özyiğit Leyla Pur, Erer Ayşen, Okumuş Gülfer, Çağatay Tülin, Kıyan Esen, Erkan Feyza

机构信息

Department of Allergy and Immunology, Koç University Faculty of Medicine, İstanbul, Turkey.

Department of Chest Diseases, İstanbul University Faculty of Medicine, İstanbul, Turkey.

出版信息

Turk Thorac J. 2016 Apr;17(2):82-83. doi: 10.5578/ttj.17.2.017. Epub 2016 Apr 1.

DOI:10.5578/ttj.17.2.017
PMID:29404130
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5792123/
Abstract

Reactive airway dysfunction syndrome (RADS) is a variant of irritant-induced asthma that develops in subjects without prior bronchoobstructive disease, following high-level exposure to nonimmunogenic irritants. Recommended maintenance treatment for RADS is not different from asthma. But in some cases, severe symptoms may persist despite the bronchodilators and corticosteroids. We describe the first case of a patient with RADS, unresponsive to all medical agents, who was successfully treated with lidocaine.

摘要

反应性气道功能障碍综合征(RADS)是刺激性诱发哮喘的一种变体,发生于无既往支气管阻塞性疾病的个体,在高浓度接触非免疫原性刺激物之后。RADS推荐的维持治疗与哮喘并无不同。但在某些情况下,尽管使用了支气管扩张剂和皮质类固醇,严重症状仍可能持续。我们描述了首例RADS患者,对所有药物均无反应,而利多卡因成功治愈了该患者。