Department of Immunology, University of Toronto, Toronto, ON M5S 1A7, Canada.
Trends Immunol. 2021 Jun;42(6):461-463. doi: 10.1016/j.it.2021.04.008. Epub 2021 May 10.
How does the immune system tailor effector function to particular threats? Krueger et al. reveal that infection with Salmonella enterica (SE), but not with influenza A virus (IAV), drives interleukin (IL)-12-dependent outgrowth of interferon (IFN)-γ type 1 T helper (Th1) cells, leading to superior protection against this phagosomal pathogen. Among these cells are ZEB2-dependent cytotoxic Th1 cells marked by CX3CR1 expression.
免疫系统如何针对特定威胁调整效应功能？Krueger 等人揭示，感染沙门氏菌（SE）而非甲型流感病毒（IAV）会促使白细胞介素（IL）-12 依赖性干扰素（IFN）-γ 型 1 T 辅助（Th1）细胞的扩增，从而对这种吞噬体病原体提供更好的保护。在这些细胞中，依赖 ZEB2 的细胞毒性 Th1 细胞被 CX3CR1 表达所标记。
