Neochoritis Constantinos G, Ghonchepour Ehsan, Miraki Maryam Kazemi, Zarganes-Tzitzikas Tryfon, Kurpiewska Katarzyna, Kalinowska-Tłuścik Justyna, Dömling Alexander
Department of Pharmacy, Drug Design group, University of Groningen, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Faculty of Chemistry, Jagiellonian University, Ingardena Street 3, 30-060 Kraków, Poland.
European J Org Chem. 2019 Jan 10;2019(1):50-55. doi: 10.1002/ejoc.201801588. Epub 2018 Nov 22.
3D structural information was obtained from mono-, di- and trisaccharide formamide and isocyanide derivatives by analysis of their X-ray crystal structure and NMR spectroscopy. The isocyanide anomeric effect was observed. Data mining of the Cambridge Structural Database (CSD) was performed and statistically confirmed our findings. Application of the glycoside isocyanides in the synthesis of novel glycoconjugates as drug-like scaffolds by MCR chemistry underscores the usefulness of the novel building blocks.
通过对单糖、二糖和三糖甲酰胺及异腈衍生物的X射线晶体结构和核磁共振光谱分析，获得了3D结构信息。观察到了异腈端基异构效应。对剑桥结构数据库（CSD）进行了数据挖掘，并从统计学上证实了我们的发现。通过MCR化学将糖苷异腈应用于新型糖缀合物的合成，作为类药物支架，突出了这些新型结构单元的实用性。
