通过多组分反应构建糖缀合物文库
An Access to Glycoconjugate Libraries through Multicomponent Reactions.
作者信息
Lockhoff Oswald
机构信息
Bayer AG, Central Research, ZF-WF Q18, D-51368 Leverkusen (Germany), Fax: (+49) 214-3050070.
出版信息
Angew Chem Int Ed Engl. 1998 Dec 31;37(24):3436-3439. doi: 10.1002/(SICI)1521-3773(19981231)37:24<3436::AID-ANIE3436>3.0.CO;2-Z.
Abstract
Four-component reactions: The Ugi reaction of four suitably functionalized carbohydrate derivatives (as a per-O-benzylated amine, an aldehyde, a carboxylic acid, and an isocyanide) allow the effective assembly of diverse compound libraries. The complex glycoconjugates formed can be deprotected (see the picture for an example), and the resulting glycomimetics are of high interest for screening purposes.
摘要
四组分反应
四种适当官能化的碳水化合物衍生物（作为全 O-苄基化胺、醛、羧酸和异氰化物）的乌吉反应能够有效构建多样的化合物库。形成的复杂糖缀合物可以进行脱保护（示例见图），所得的糖模拟物对于筛选目的具有高度价值。
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