Department of Anesthesiology, Hamadan University of Medical Sciences, Hamadan, Iran.
Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.
Oxid Med Cell Longev. 2021 Apr 23;2021:6611740. doi: 10.1155/2021/6611740. eCollection 2021.
Severe pain, nausea, and vomiting after tonsillectomy surgery are among the issues that not only affect patient satisfaction but also may result in complications and delay patient discharge. This study was conducted to assess the effect of intravenous administration of ondansetron on the analgesic action of intravenous acetaminophen after tonsillectomy in children. . This randomized controlled trial was conducted on 53 children between the age of 3 and 12 years old who were referred to Besat Hospital Hamadan, Iran, for tonsillectomy. Patients were randomly assigned to two groups. The intervention group (I) received intravenous acetaminophen plus 0.1 mg/kg ondansetron intravenously while the control group (C) received intravenous acetaminophen plus 2 ml of normal saline intravenously. Postoperative pain severity was assessed using the Children's Hospital Eastern Ontario Pain Scale (CHEOPS). Frequency of nausea, vomiting, and need for analgesic was assessed and recorded four times, at recovery unit, after 6, 12, and 24 hours postsurgery. Data analysis was performed at 95% confidence level using the statistical package for social sciences (SPSS) software version 21.
The number of patients in groups I and C was 27 and 26 patients, respectively. Mean pain score in I and C groups was 4.48 and 2.88 at recovery unit, 2.74 and 2.04 after 6 hours, 1.67 and 0.81 after 12 hours, and 0.67 and 0.20 after 24 hours postsurgery, respectively. Frequency of nausea at recovery unit was 23.1% in I group and 0.0% in group C ( = 0.010) while the mean number of analgesic requirements in I and C groups was 1.07 and 0.56 times, respectively ( = 0.027).
Intravenous administration of 0.1 mg/kg ondansetron reduces the analgesic action of intravenous acetaminophen after tonsillectomy in 3 to 12-year-old children.
扁桃体切除术后出现剧烈疼痛、恶心和呕吐等问题，不仅会影响患者满意度，还可能导致并发症并延迟患者出院。本研究旨在评估静脉注射昂丹司琼对儿童扁桃体切除术后静脉注射扑热息痛的镇痛作用。这是一项随机对照试验，在伊朗哈马丹 Besat 医院对 53 名年龄在 3 至 12 岁之间的扁桃体切除患者进行了研究。患者被随机分为两组。干预组（I 组）接受静脉注射扑热息痛加 0.1mg/kg 昂丹司琼静脉注射，而对照组（C 组）接受静脉注射扑热息痛加 2ml 生理盐水静脉注射。术后疼痛严重程度采用东安大略儿童医院疼痛量表（CHEOPS）评估。记录四次恶心、呕吐和需要镇痛的频率，分别在恢复室、术后 6、12 和 24 小时。使用统计软件包（SPSS）版本 21 在 95%置信水平下进行数据分析。
I 组和 C 组患者人数分别为 27 例和 26 例。I 组和 C 组患者在恢复室的平均疼痛评分分别为 4.48 和 2.88，术后 6 小时分别为 2.74 和 2.04，12 小时分别为 1.67 和 0.81，24 小时分别为 0.67 和 0.20。I 组患者在恢复室恶心的频率为 23.1%，C 组为 0.0%（=0.010），而 I 组和 C 组患者需要镇痛的平均次数分别为 1.07 次和 0.56 次（=0.027）。
在 3 至 12 岁儿童中，静脉注射 0.1mg/kg 昂丹司琼可降低扁桃体切除术后静脉注射扑热息痛的镇痛作用。
