Laboratory of Bacteriology and Mycobacteria, Corporación para Investigaciones Biológicas (CIB), Medellín, Colombia.
Escuela de Ciencias de la Salud, Universidad Pontificia Bolivariana, Medellín, Colombia.
Front Cell Infect Microbiol. 2021 Apr 26;11:659997. doi: 10.3389/fcimb.2021.659997. eCollection 2021.
(MABC is one of the most clinically relevant species among nontuberculous mycobacteria. MABC's prevalence has increased over the last two decades. Although these changes can be explained by improvements in microbiological and molecular techniques for identifying species and subspecies, a higher prevalence of chronic lung diseases may contribute to higher rates of MABC. High rates of antimicrobial resistance are seen in MABC, and patients experience multiple relapses with low cure rates. This review aims to integrate existing knowledge about MABC epidemiology, microbiological identification and familiarize readers with molecular mechanisms of resistance and therapeutic options for pulmonary infections with MABC.
（MABC 是非结核分枝杆菌中最具临床相关性的物种之一。在过去的二十年中，MABC 的患病率有所增加。尽管这些变化可以用改进的微生物学和分子技术来识别物种和亚种来解释，但慢性肺部疾病的高发可能导致 MABC 的发病率更高。MABC 中存在高比例的抗生素耐药性，患者经历多次复发，治愈率低。本综述旨在整合关于 MABC 流行病学、微生物学鉴定的现有知识，并使读者熟悉 MABC 肺部感染的耐药分子机制和治疗选择。）
