Argyropoulos Theodoros, Korakas Emmanouil, Gikas Aristofanis, Kountouri Aikaterini, Kostaridou-Nikolopoulou Stavroula, Raptis Athanasios, Lambadiari Vaia
Department of Paediatrics, Penteli Children's Hospital, Athens, Greece.
Second Department of Internal Medicine and Research Institute, Medical School, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Front Pediatr. 2021 Apr 26;9:670976. doi: 10.3389/fped.2021.670976. eCollection 2021.
Hyperglycemia is a common manifestation in the course of severe disease and is the result of acute metabolic and hormonal changes associated with various factors such as trauma, stress, surgery, or infection. Numerous studies demonstrate the association of adverse clinical events with stress hyperglycemia. This article briefly describes the pathophysiological mechanisms which lead to hyperglycemia under stressful circumstances particularly in the pediatric and adolescent population. The importance of prevention of hyperglycemia, especially for children, is emphasized and the existing models for the prediction of diabetes are presented. The available studies on the association between stress hyperglycemia and progress to type 1 diabetes mellitus are presented, implying a possible role for stress hyperglycemia as part of a broader prognostic model for the prediction and prevention of overt disease in susceptible patients.
高血糖是重症病程中的常见表现，是由创伤、应激、手术或感染等多种因素引起的急性代谢和激素变化所致。大量研究表明不良临床事件与应激性高血糖有关。本文简要描述了导致应激状态下高血糖的病理生理机制，尤其是在儿童和青少年人群中。强调了预防高血糖的重要性，特别是对儿童而言，并介绍了现有的糖尿病预测模型。还介绍了关于应激性高血糖与1型糖尿病进展之间关联的现有研究，这意味着应激性高血糖可能作为更广泛的预测模型的一部分，用于预测和预防易感患者的显性疾病。
