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立体定向放射治疗作为胰腺癌新辅助治疗一部分的时机和设计:是时候改变了吗?

The timing and design of stereotactic radiotherapy approaches as a part of neoadjuvant therapy in pancreatic cancer: Is it time for change?

作者信息

Ryckman Jeffrey M, Reames Bradley N, Klute Kelsey A, Hall William A, Baine Michael J, Abdel-Wahab May, Lin Chi

机构信息

Department of Radiation Oncology, West Virginia University Cancer Institute, Parkersburg, WV, USA.

Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA.

出版信息

Clin Transl Radiat Oncol. 2021 Apr 19;28:124-128. doi: 10.1016/j.ctro.2021.04.002. eCollection 2021 May.

Abstract

Stereotactic Radiotherapy (SRT) over 5-15 days can be interdigitated without delaying chemotherapy. Bridging chemotherapy may allow for extended intervals to surgery, potentially improving sterilization of surgical margins and overall survival. SRT for pancreatic adenocarcinoma should not be limited to the tumor, and should consider hypofractionated approaches to regional nodes.

摘要

在5至15天内进行的立体定向放射治疗(SRT)可以相互穿插进行,而不会延迟化疗。桥接化疗可能会延长至手术的间隔时间,有可能提高手术切缘的灭菌效果和总体生存率。胰腺癌的SRT不应局限于肿瘤,而应考虑对区域淋巴结采用大分割放疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/321e/8085778/08352e4ba260/gr1.jpg

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