Janse van Rensburg Walter J, de Kock André, Bester Chené, Kloppers Jean F
Human Molecular Biology Unit, School of Biomedical Sciences, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.
Department of Haematology and Cell Biology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.
Heliyon. 2021 Apr 21;7(4):e06850. doi: 10.1016/j.heliyon.2021.e06850. eCollection 2021 Apr.
Human Leucocyte Antigens (HLA) play a vital role in disease pathogenesis and transplant rejection. HLA-typing is a useful tool in predicting disease progression and to identify potential organ donors. Due to human migration and known ethnic variation, frequent targeted HLA sequencing of specific populations is crucial to increase their representation in global reference panels.
We performed a retrospective file audit of all HLA-typings done in our setting from 2005-2019. We discuss data for the major HLA-A, HLA-B, HLA-C, and HLA-DRB1 allele groups.
Overall, the most common allele groups were HLA-A∗02, HLA-B∗15, HLA-C∗07 and HLA-DRB1∗03. For the African descent group, the most common alleles were HLA-A∗30, HLA-B∗15, HLA-C∗07 and HLA-DRB1∗03. For the European descent group, the most common alleles were HLA-A∗02, HLA-B∗07, HLA-C∗07 and HLA-DRB1∗15. For the mixed ancestry group, the most common allele groups were HLA-A∗02, HLA-B∗15, HLA-C∗02 and HLA-DRB1∗13. HLA-B∗44 was identified as the most common allele group in patients with renal failure.
The significant variation within the HLA frequencies between the different ethnic groups highlights the value of population-specific HLA-typing. Furthermore, the identification of HLA-B∗44 as a prominent HLA in our renal failure population warrants in-depth investigation of this group.
人类白细胞抗原（HLA）在疾病发病机制和移植排斥反应中起着至关重要的作用。HLA分型是预测疾病进展和识别潜在器官供体的有用工具。由于人类迁移和已知的种族差异，对特定人群进行频繁的靶向HLA测序对于增加其在全球参考面板中的代表性至关重要。
我们对2005年至2019年在我们机构进行的所有HLA分型进行了回顾性文件审核。我们讨论了主要HLA-A、HLA-B、HLA-C和HLA-DRB1等位基因组的数据。
总体而言，最常见的等位基因组是HLA-A∗02、HLA-B∗15、HLA-C∗07和HLA-DRB1∗03。对于非洲裔群体，最常见的等位基因是HLA-A∗30、HLA-B∗15、HLA-C∗07和HLA-DRB1∗03。对于欧洲裔群体，最常见的等位基因是HLA-A∗02、HLA-B∗07、HLA-C∗07和HLA-DRB1∗15。对于混合血统群体，最常见的等位基因组是HLA-A∗02、HLA-B∗15、HLA-C∗02和HLA-DRB1∗13。HLA-B∗44被确定为肾衰竭患者中最常见的等位基因组。
不同种族群体之间HLA频率的显著差异凸显了特定人群HLA分型的价值。此外，在我们的肾衰竭人群中，HLA-B∗44被确定为突出的HLA，这值得对该群体进行深入研究。
