Ikhtiar Adnan M, Jazairi Batoul, Khansa Issam, Othman Ahmad
FCM Lab., Molecular Biology & Biotechnology Department, Atomic Energy Commission of Syria (AECS), P.O. Box 6091, Damascus, Syrian Arab Republic.
Department of Anatomy, Histology and Embryology, Medicine College, Damascus University, Damascus, Syria.
BMC Res Notes. 2018 May 21;11(1):324. doi: 10.1186/s13104-018-3427-1.
The HLA system is known to be the most polymorphic genetic loci in humans. Distribution and frequencies of HLA alleles are highly variable among different human ethnic groups. The HLA system has an important role in disease susceptibility and resistance, especially in autoimmune diseases and cancer. This study is the first report about HLA genetic variability and haplotypes among Syrians. Frequency of the HLA class I (A, B and C) alleles was determined in 105 healthy unrelated Syrian individuals from different regions in Syria. We also studied the associated haplotypes frequencies. Alleles frequencies were compared with those reported for other populations.
Fifty-eight HLA class I alleles were observed in Syrians including 15 for HLA-A, 28 for HLA-B and 15 for HLA-C. We observed 37 HLA-A/C haplotypes, 32 B/C, and 31 A/B haplotypes. The most frequent haplotypes were A01/C04, A02/C07, A02/B35, and B35/C04. In conclusions, our preliminary study suggests a high variability in HLA class I alleles in the Syrian population. This study also gives a general reference database about the genetic pool distribution of HLA class I alleles among Syrians and can be consulted for HLA related diseases.
已知人类白细胞抗原（HLA）系统是人类中多态性最高的基因座。HLA等位基因的分布和频率在不同人类种族群体中高度可变。HLA系统在疾病易感性和抵抗力方面发挥着重要作用，尤其是在自身免疫性疾病和癌症中。本研究是关于叙利亚人HLA基因变异性和单倍型的首次报告。在来自叙利亚不同地区的105名健康无亲缘关系的叙利亚个体中确定了HLA I类（A、B和C）等位基因的频率。我们还研究了相关单倍型的频率。将等位基因频率与其他人群报告的频率进行了比较。
在叙利亚人中观察到58种HLA I类等位基因，其中HLA-A有15种，HLA-B有28种，HLA-C有15种。我们观察到37种HLA-A/C单倍型、32种B/C单倍型和31种A/B单倍型。最常见的单倍型是A01/C04、A02/C07、A02/B35和B35/C04。总之，我们的初步研究表明叙利亚人群中HLA I类等位基因存在高度变异性。本研究还给出了一个关于叙利亚人HLA I类等位基因遗传库分布的通用参考数据库，可用于HLA相关疾病的参考。
