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Plasma concentrations of remdesivir metabolite in a critical COVID-19 patient needing continuous venovenous haemodialysis.

作者信息

Tempestilli Massimo, Stazi Giulia Valeria, Maffongelli Gaetano, Marini Maria Cristina, Ascoli Bartoli Tommaso, Ippolito Giuseppe, Nicastri Emanuele, Marchioni Luisa, Agrati Chiara

机构信息

Immunology and Pharmacology Laboratory, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, via Portuense 292, 00149, Rome, Italy.

出版信息

Eur J Clin Pharmacol. 2021 Oct;77(10):1583-1585. doi: 10.1007/s00228-021-03128-7. Epub 2021 May 12.

DOI:10.1007/s00228-021-03128-7
PMID:33982133
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8116063/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f29d/8116063/52f90969a36d/228_2021_3128_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f29d/8116063/52f90969a36d/228_2021_3128_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f29d/8116063/52f90969a36d/228_2021_3128_Fig1_HTML.jpg

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本文引用的文献

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Pharmacokinetics of remdesivir in a COVID-19 patient with end-stage renal disease on intermittent haemodialysis.瑞德西韦在一名接受间歇性血液透析的终末期肾病新冠肺炎患者中的药代动力学。
J Antimicrob Chemother. 2021 Feb 11;76(3):825-827. doi: 10.1093/jac/dkaa500.
2
Remdesivir and GS-441524 plasma concentrations in patients with end-stage renal disease on haemodialysis.接受血液透析的终末期肾病患者中瑞德西韦和GS-441524的血浆浓度。
J Antimicrob Chemother. 2021 Feb 11;76(3):822-825. doi: 10.1093/jac/dkaa472.
3
Removal of Remdesivir's Metabolite GS-441524 by Hemodialysis in a Double Lung Transplant Recipient with COVID-19.
COVID-19 患者双肺移植术后应用血液透析清除瑞德西韦代谢产物 GS-441524。
Antimicrob Agents Chemother. 2020 Oct 20;64(11). doi: 10.1128/AAC.01521-20.
4
Pharmacokinetics of remdesivir and GS-441524 in two critically ill patients who recovered from COVID-19.两例 COVID-19 重症患者康复后瑞德西韦和 GS-441524 的药代动力学。
J Antimicrob Chemother. 2020 Oct 1;75(10):2977-2980. doi: 10.1093/jac/dkaa239.
5
Covid-19: Remdesivir is recommended for authorisation by European Medicines Agency.新冠病毒-19:欧洲药品管理局建议批准瑞德西韦。
BMJ. 2020 Jun 29;369:m2610. doi: 10.1136/bmj.m2610.
6
Remdesivir in Patients with Acute or Chronic Kidney Disease and COVID-19.瑞德西韦用于急性或慢性肾脏病合并新型冠状病毒肺炎患者的研究
J Am Soc Nephrol. 2020 Jul;31(7):1384-1386. doi: 10.1681/ASN.2020050589. Epub 2020 Jun 8.
7
Development and validation of a UHPLC-MS/MS method for quantification of the prodrug remdesivir and its metabolite GS-441524: a tool for clinical pharmacokinetics of SARS-CoV-2/COVID-19 and Ebola virus disease.建立并验证 UHPLC-MS/MS 法测定前药瑞德西韦及其代谢产物 GS-441524 的浓度:一种用于 SARS-CoV-2/COVID-19 和埃博拉病毒病临床药代动力学的工具。
J Antimicrob Chemother. 2020 Jul 1;75(7):1772-1777. doi: 10.1093/jac/dkaa152.