Smekuna F A, Minasova G S, Kulikova N N
Antibiotiki. 1977 Dec;22(12):1121-5.
The effect of some semi-synthetic penicillins, such as methicillin and oxacillin and cephalosporings, such as cephaloridin on the condition of the blood coagulation system in 85 patients with postnatal mastitis and endomyometritis was studied. It was shown that the above antibiotics had no significant effect on the parameters of the blood coagulating system. A decrease in the fibrinogen level was found in the mastitis patients treated with semi-synthetic penicillins and cephaloridin. An increase in the prothrombins index in the patients treated with methicillin oxacillin was shown. The use of the semi-synthetic penicillins and cephaloridin for the therapy of the puerpera with endomyometritis resulted in prolongation of the recalcification period. A decrease in the fibrinolytic activity most pronounced in therapy with cephaloridin was also found. Therefore, the above changes in the blood coagulating system of the puerpera with postnatal infections subjected to short-term treatment courses were insignificant and required no special correction.
研究了某些半合成青霉素（如甲氧西林和苯唑西林）以及头孢菌素（如头孢噻啶）对85例产后乳腺炎和子宫内膜炎患者凝血系统状况的影响。结果表明，上述抗生素对凝血系统参数无显著影响。在用半合成青霉素和头孢噻啶治疗的乳腺炎患者中发现纤维蛋白原水平降低。在用甲氧西林和苯唑西林治疗的患者中显示凝血酶原指数升高。使用半合成青霉素和头孢噻啶治疗患有子宫内膜炎的产妇会导致再钙化期延长。还发现用头孢噻啶治疗时纤维蛋白溶解活性降低最为明显。因此，接受短期治疗疗程的产后感染产妇凝血系统的上述变化不显著，无需特殊纠正。
