Shanghai Heart Failure Research Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
J Diabetes Investig. 2021 Nov;12(11):2046-2053. doi: 10.1111/jdi.13573. Epub 2021 Jun 6.
AIMS/INTRODUCTION: To compare the association of hypertension plus hyperuricemia with four insulin resistance surrogates, including glucose and triglycerides (TyG index), TyG index with body mass index (TyG-BMI), the ratio of triglycerides divided by high-density lipoprotein cholesterol (TG/HDL-C) and metabolic score for insulin resistance (METS-IR).
Data from a cross-sectional epidemiological study enrolling a representative population sample aged ≥65 years were used to calculate the four indexes. The association with hypertension plus hyperuricemia and insulin resistance surrogates was examined with multivariate logistic regression and receiver operating characteristic.
A total of 4,352 participants were included, including 93 (2.1%) patients with hyperuricemia alone, 2,875 (66.1%) with hypertension alone and 587 (13.5%) with hypertension plus hyperuricemia. Mutivariate logistic regression showed that TyG index, TyG-BMI, TG/HDL-C and METS-IR were all significantly correlated with hyperuricemia, hypertension and hypertension plus hyperuricemia. Compared with the lowest quartile, the odds ratios (OR) of the highest quartile of the four indicators for hypertension plus hyperuricemia were TyG index: OR 6.39 (95% confidence interval [CI] 4.17-9.78); TyG-BMI: OR 8.54 (95% CI 5.58-13.09); TG/HDL-C: OR 7.21 (95% CI 4.72-11.01); METS-IR: OR 9.30 (95% CI 6.00-14.43), respectively. TyG-BMI and METS-IR had moderate discriminative abilities for hypertension plus hyperuricemia and the AUC values were 0.72 (95% CI 0.70-0.74) and 0.73 (95% CI 0.70-0.75).
The present study suggested that TyG index, TyG-BMI, TG/HDL-C and METS-IR had a significant correlation with hypertension plus hyperuricemia, and TyG-BMI and METS-IR had discriminative abilities for hypertension plus hyperuricemia.
目的/引言：本研究旨在比较高血压合并高尿酸血症与 4 种胰岛素抵抗替代指标（血糖和甘油三酯[TyG 指数]、TyG 指数与体重指数的比值[TyG-BMI]、甘油三酯与高密度脂蛋白胆固醇的比值[TG/HDL-C]和代谢胰岛素抵抗评分[METS-IR]）的相关性。
本研究使用了一项横断面流行病学研究的数据，该研究纳入了年龄≥65 岁的代表性人群样本，以计算这 4 项指标。采用多元逻辑回归和受试者工作特征曲线分析了这些指标与高血压合并高尿酸血症的相关性。
共纳入 4352 名参与者，其中 93 名（2.1%）患者仅患有高尿酸血症，2875 名（66.1%）患者仅患有高血压，587 名（13.5%）患者患有高血压合并高尿酸血症。多变量逻辑回归显示，TyG 指数、TyG-BMI、TG/HDL-C 和 METS-IR 均与高尿酸血症、高血压和高血压合并高尿酸血症显著相关。与最低四分位数相比，4 项指标中最高四分位数的比值比（OR）为 TyG 指数：OR 6.39（95%置信区间 [CI] 4.17-9.78）；TyG-BMI：OR 8.54（95% CI 5.58-13.09）；TG/HDL-C：OR 7.21（95% CI 4.72-11.01）；METS-IR：OR 9.30（95% CI 6.00-14.43）。TyG-BMI 和 METS-IR 对高血压合并高尿酸血症具有中等的判别能力，AUC 值分别为 0.72（95% CI 0.70-0.74）和 0.73（95% CI 0.70-0.75）。
本研究表明，TyG 指数、TyG-BMI、TG/HDL-C 和 METS-IR 与高血压合并高尿酸血症显著相关，TyG-BMI 和 METS-IR 对高血压合并高尿酸血症具有判别能力。
