Miao Huanhuan, Zhou Zhanyang, Yin Zheng, Li Xue, Zhang Yuhui, Zhang Yuqing, Zhang Jian
State Key Laboratory of Cardiovascular Disease, Heart Failure Center, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
J Clin Hypertens (Greenwich). 2025 Mar;27(3):e70022. doi: 10.1111/jch.70022.
The weight-adjusted waist index (WWI) is a novel indicator that could estimate body fat and muscle mass. This study aimed to investigate the relationship between WWI and hypertension plus hyperuricemia (HTN-HUA). The data were obtained from the National Health and Nutrition Examination Survey (NHANES) database from 1999 to 2018. Logistic regression analyses were used to explore the association between WWI with HTN-HUA, hypertension (HTN) alone, and hyperuricemia (HUA) alone. Restricted cubic spline (RCS) analyses were employed to examine potential nonlinear associations. Receiver operating characteristic (ROC) curves were utilized to assess the predictive ability of WWI. A total of 16 294 participants were included, among whom 2280 (12%) were diagnosed with HTN-HUA, 5148 (28%) with HTN alone, and 1252 (9%) with HUA alone. WWI was significantly associated with HTN-HUA, HTN alone, and HUA alone after adjusting for potential confounders. Compared to the lowest quartiles of WWI, the odds ratios of the highest quartiles were 2.13 (95% confidence interval [CI]: 1.59-2.83) for HTN-HUA, 1.28 (95% CI: 1.08-1.5) for HTN alone, and 1.6 (95% CI: 1.18-2.16) for HUA alone. RCS analyses demonstrated a nonlinear association between WWI and HTN-HUA. The fully adjusted model, which included WWI, exhibited a moderate predictive ability for HTN-HUA (area under the curve [AUC]: 0.804, 95% CI 0.796-0.813). The association between WWI and HTN-HUA was more prominent among young individuals and those with normal weight. The study suggested that a significant and nonlinear association between WWI and HTN-HUA. WWI had the potential to facilitate the early detection of HTN-HUA.
体重调整腰围指数（WWI）是一种可用于估计体脂和肌肉量的新型指标。本研究旨在探究WWI与高血压合并高尿酸血症（HTN-HUA）之间的关系。数据来源于1999年至2018年的美国国家健康与营养检查调查（NHANES）数据库。采用逻辑回归分析来探究WWI与HTN-HUA、单纯高血压（HTN）以及单纯高尿酸血症（HUA）之间的关联。运用受限立方样条（RCS）分析来检验潜在的非线性关联。采用受试者工作特征（ROC）曲线来评估WWI的预测能力。总共纳入了16294名参与者，其中2280名（12%）被诊断为HTN-HUA，5148名（28%）为单纯HTN，1252名（9%）为单纯HUA。在调整潜在混杂因素后，WWI与HTN-HUA、单纯HTN以及单纯HUA均显著相关。与WWI最低四分位数相比，最高四分位数的HTN-HUA比值比为2.13（95%置信区间[CI]：1.59 - 2.83），单纯HTN为1.28（95%CI：1.08 - 1.5），单纯HUA为1.6（95%CI：1.18 - 2.16）。RCS分析表明WWI与HTN-HUA之间存在非线性关联。包含WWI的完全调整模型对HTN-HUA具有中等预测能力（曲线下面积[AUC]：0.804，95%CI 0.796 - 0.813）。WWI与HTN-HUA之间的关联在年轻人和体重正常者中更为显著。该研究表明WWI与HTN-HUA之间存在显著的非线性关联。WWI有潜力促进HTN-HUA的早期检测。
