甘油三酯葡萄糖指数与高尿酸血症之间的关联：一项剂量反应荟萃分析。

The Association Between the Triglyceride Glucose Index and Hyperuricemia: A Dose-Response Meta-Analysis.

作者信息

Wang Juan, He Qiang, Sun Wenhui, Li Wei, Yang Yuting, Cui Weiwei, Yang Xiangshan

机构信息

Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun 130021, China.

Department of Radiation Hygiene, School of Public Health, Jilin University, Changchun 130021, China.

出版信息

Nutrients. 2025 Apr 26;17(9):1462. doi: 10.3390/nu17091462.

DOI:10.3390/nu17091462

PMID:40362772

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12073563/

Abstract

The triglyceride glucose (TyG) index has been correlated with all kinds of diseases. However, its association with hyperuricemia is still a subject of controversy. This meta-analysis encompassed relevant studies on the TyG index and hyperuricemia obtained from electronic databases, from the launch date until March 2025. The effect sizes and corresponding 95% confidence intervals (CIs) were obtained using a random effects model. Twenty-six trials with 637,954 subjects were incorporated in this study. It was revealed that the TyG index was linked to hyperuricemia (OR = 2.67; 95% CI: 2.34, 3.04; < 0.001). A dose-response analysis demonstrated that with each 1 mg/dL rise in the TyG index, the risk of being diagnosed with hyperuricemia increased by 2.07 times (OR = 2.07; 95% CI: 1.89, 2.25; < 0.001). The TyG index has an association with hyperuricemia. Given the constraints identified in our meta-analysis, further cohort studies will be essential to confirm this correlation.

摘要

甘油三酯葡萄糖（TyG）指数已与各类疾病相关联。然而，其与高尿酸血症的关联仍存在争议。这项荟萃分析涵盖了从电子数据库中获取的自发布之日起至2025年3月的关于TyG指数和高尿酸血症的相关研究。使用随机效应模型获得效应大小及相应的95%置信区间（CI）。本研究纳入了26项试验，共637,954名受试者。结果显示，TyG指数与高尿酸血症相关（比值比[OR]=2.67；95%CI：2.34，3.04；P<0.001）。剂量反应分析表明，TyG指数每升高1mg/dL，被诊断为高尿酸血症的风险增加2.07倍（OR=2.07；95%CI：1.89，2.25；P<0.001）。TyG指数与高尿酸血症有关联。鉴于我们荟萃分析中发现的局限性，进一步的队列研究对于证实这种相关性至关重要。