Wan Chunpeng, Fan Xiaoyuan, Lou Zaixiang, Wang Hongxin, Olatunde Ahmed, Rengasamy Kannan R R
Jiangxi Key Laboratory for Postharvest Technology and Nondestructive Testing of Fruits & Vegetables, College of Agronomy, Jiangxi Agricultural University, Nanchang, Jiangxi, China.
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.
Crit Rev Food Sci Nutr. 2022;62(29):7976-7988. doi: 10.1080/10408398.2021.1922355. Epub 2021 May 13.
Iturin, a metabolite produced by , has a broad-spectrum antibacterial effect, and because they are secreted in the rhizosphere of plants, iturins are often mixed with many organic molecules. In recent years, people have improved their separation and purification methods but still cannot achieve simple and effective procedures, making Iturins an ideal biological control agent for insects and bacteria; commercial value still cannot be realized. With the in-depth studies of Iturins, its anti-cancer, hemolysis and other biological activities have gradually been discovered. This article reviews the branches of the Iturin family, structural features of these metabolite, separation and purification methods used for producing it, culture optimization, and various biological activities of the Iturin family, such as insecticidal, antibacterial, hemolytic and anticarcinogenic properties, among others have been summarized. Furthermore, this review revealed some commercial applications of Iturins and their relevance in research works. For example, in food packaging, clean water has good development potential.This can promote the commercial application of Iturins instead of other chemical and biological control agents that are environmentally friendly, pollution-free and have no side effects on humans. Furthermore, work documented anticancer, hemolytic and other biological activities of Iturin.
伊枯草菌素是由[具体产生菌]产生的一种代谢产物，具有广谱抗菌作用，并且由于它们在植物根际分泌，伊枯草菌素常与许多有机分子混合。近年来，人们改进了它们的分离和纯化方法，但仍无法实现简单有效的程序，这使得伊枯草菌素成为昆虫和细菌的理想生物防治剂；其商业价值仍无法实现。随着对伊枯草菌素研究的深入，其抗癌、溶血等生物活性逐渐被发现。本文综述了伊枯草菌素家族的分支、这些代谢产物的结构特征、用于生产它的分离和纯化方法、培养优化以及伊枯草菌素家族的各种生物活性，如杀虫、抗菌、溶血和抗癌特性等进行了总结。此外，本综述揭示了伊枯草菌素的一些商业应用及其在研究工作中的相关性。例如，在食品包装、清洁用水方面具有良好的发展潜力。这可以促进伊枯草菌素替代其他对环境友好、无污染且对人类无副作用的化学和生物防治剂的商业应用。此外，文献记载了伊枯草菌素的抗癌、溶血等生物活性。
