ENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, China.
NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China.
Arch Toxicol. 2021 Aug;95(8):2613-2623. doi: 10.1007/s00204-021-03067-3. Epub 2021 May 13.
Vestibular hair cells are mechanosensory receptors that are capable of detecting changes in head position and thereby allow animals to maintain their posture and coordinate their movement. Vestibular hair cells are susceptible to ototoxic drugs, aging, and genetic factors that can lead to permanent vestibular dysfunction. Vestibular dysfunction mainly results from the injury of hair cells, which are located in the vestibular sensory epithelium. This review summarizes the mechanisms of different factors causing vestibular hair cell damage and therapeutic strategies to protect vestibular hair cells.
前庭毛细胞是机械感受器，能够检测头部位置的变化，从而使动物维持姿势并协调运动。前庭毛细胞易受耳毒性药物、衰老和遗传因素的影响，这些因素可导致永久性前庭功能障碍。前庭功能障碍主要是由于位于前庭感觉上皮的毛细胞损伤所致。本综述总结了不同因素导致前庭毛细胞损伤的机制以及保护前庭毛细胞的治疗策略。
