Department of Surgery, Dankook University College of Medicine, Cheonan-si, South Korea.
Department of Surgery, Keimyung University school of Medicine, Daegu, South Korea.
Adv Exp Med Biol. 2021;1187:591-599. doi: 10.1007/978-981-32-9620-6_31.
The status of the axillary lymph nodes is one of the most important prognostic factors for patients with breast cancer. For over 100 years, axillary lymph node dissection was the standard approach to obtain and manage axillar lymph node, but now, sentinel lymph node biopsy has become a standard approach with less morbidity and equal accuracy in clinical node-negative patients. In addition, numerous studies are on the way to omit axillary lymph node dissection in specific patient subgroups. The recent trials like the ACOSOG Z0011 showed the evidence that omitting an ALND in patients with low burden nodal disease is safe in patients receiving whole-breast radiation. To reduce the use of ALND is the goal to consider when selecting an axillary management strategy.
腋窝淋巴结的状态是乳腺癌患者最重要的预后因素之一。100 多年来,腋窝淋巴结清扫术一直是获取和处理腋窝淋巴结的标准方法,但现在,前哨淋巴结活检已成为一种标准方法,在临床淋巴结阴性患者中具有较低的发病率和同等的准确性。此外,还有许多研究正在进行中,以期在特定的患者亚组中省略腋窝淋巴结清扫术。最近的试验,如 ACOSOG Z0011,表明在接受全乳放疗的患者中,对于低淋巴结负荷疾病的患者,省略 ALND 是安全的。在选择腋窝管理策略时,减少 ALND 的使用是需要考虑的目标。