通过异氰、丙二烯酸酯和 2-氨基查耳酮的多组分反应实现四环四氢喹啉衍生物的非对映选择性合成。
Diastereoselective Synthesis of Tetracyclic Tetrahydroquinoline Derivative Enabled by Multicomponent Reaction of Isocyanide, Allenoate, and 2-Aminochalcone.
机构信息
Department of Chemistry, College of Sciences & Institute for Sustainable Energy, Shanghai University, 99 Shangda Road, Shanghai 200444, People's Republic of China.
Anhui Province Key Laboratory for Degradation and Monitoring of Pollution of the Environment, School of Chemistry & Materials Engineering, Fuyang Normal University, Fuyang, Anhui 236037, People's Republic of China.
出版信息
Org Lett. 2021 Jun 4;23(11):4094-4098. doi: 10.1021/acs.orglett.1c00912. Epub 2021 May 13.
We report here a multicomponent protocol to assemble several polycyclic dihydropyran-fused tetrahydroquinoline structures with excellent diastereoselectivity. This procedure employs simple feedstocks to accomplish a series of diverse structures, which is difficult to attain by traditional sequences.
我们在此报告了一种多组分协议，可用于立体选择性极好地组装几种多环二氢吡喃并四氢喹啉结构。该方法采用简单的原料完成了一系列不同的结构，这是传统序列难以实现的。
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