5-脂氧合酶作为一种针对与年龄相关的脑疾病的新兴靶点。
5-Lipoxygenase as an emerging target against age-related brain disorders.
机构信息
College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, 311121, China; Hangzhou Key Laboratory of Medical Neurobiology, Hangzhou Normal University, Hangzhou, 311121, China; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, China.
Department of Neurology, Zhejiang Hospital, Hangzhou, 310030, China.
出版信息
Ageing Res Rev. 2021 Aug;69:101359. doi: 10.1016/j.arr.2021.101359. Epub 2021 May 10.
Neuroinflammation is a common feature of age-related brain disorders including Alzheimer's disease (AD), Parkinson's disease (PD) and cerebral ischemia. 5-lipoxygenase (5-LOX), a proinflammatory enzyme, modulates inflammation by generating leukotrienes. Abnormal activation of 5-LOX and excessive production of leukotrienes have been detected in the development of age-related brain pathology. In this review, we provide an update on the current understanding of 5-LOX activation and several groups of functionally related inhibitors. In addition, the modulatory roles of 5-LOX in the pathogenesis and progression of the age-related brain disorders have been comprehensively highlighted and discussed. Inhibition of 5-LOX activation may represent a promising therapeutic strategy for AD, PD and cerebral ischemia.
神经炎症是与年龄相关的脑疾病（包括阿尔茨海默病（AD）、帕金森病（PD）和脑缺血）的共同特征。5-脂氧合酶（5-LOX）是一种促炎酶，通过生成白三烯来调节炎症。在与年龄相关的脑病理发展过程中，已检测到 5-LOX 的异常激活和白三烯的过度产生。在这篇综述中，我们提供了对 5-LOX 激活及其几组功能相关抑制剂的最新理解。此外，还全面强调和讨论了 5-LOX 在与年龄相关的脑疾病发病机制和进展中的调节作用。抑制 5-LOX 的激活可能代表了 AD、PD 和脑缺血的一种有前途的治疗策略。
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