Departments of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Department of Radiology and National Center for Child Health and Development, Tokyo, Japan.
Cancer Treat Rev. 2021 Jul;98:102209. doi: 10.1016/j.ctrv.2021.102209. Epub 2021 Apr 16.
Children and adolescents and young adults (AYAs) with cancer are often treated with a multidisciplinary approach. This includes use of radiotherapy, which is important for local control, but may also cause adverse events in the long term, including second cancer. The risks for limited growth and development, endocrine dysfunction, reduced fertility and second cancer in children and AYAs are reduced by proton beam therapy (PBT), which has a dose distribution that decreases irradiation of normal organs while still targeting the tumor. To define the outcomes and characteristics of PBT in cancer treatment in pediatric and AYA patients, this document was developed by the Japanese Society for Radiation Oncology (JASTRO) and the Japanese Society of Pediatric Hematology/Oncology (JSPHO).
儿童、青少年和青年癌症患者通常采用多学科治疗方法。这包括放疗的应用，放疗对于局部控制很重要，但也可能导致长期不良事件，包括第二癌症。质子束治疗（PBT）可降低儿童和青少年生长发育受限、内分泌功能障碍、生育能力降低和第二癌症的风险，其剂量分布可减少对正常器官的照射，同时仍能瞄准肿瘤。为了明确质子束治疗在儿科和青少年癌症患者治疗中的结果和特点，本文件由日本放射肿瘤学会（JASTRO）和日本小儿血液学/肿瘤学会（JSPHO）制定。
