Department of Otolaryngology, Head and Neck Surgery, Wroclaw Medical University, Borowska 213, 50-556, Wrocław, Poland.
Curr Oncol Rep. 2024 Nov;26(11):1380-1387. doi: 10.1007/s11912-024-01592-9. Epub 2024 Aug 8.
Head and neck cancers rank as the seventh most common cancer worldwide, nearly half of which result in death. The most common treatment methods for head and neck cancers include radiotherapy and surgery. Proton therapy has emerged in radiotherapy for cases where tumors are located near anatomically sensitive areas where the radiation dose must be strictly limited. The purpose of the work is to discuss the role of the proton therapy in the treatment in various types of cancer, and particularly head and neck tumors.
Proton therapy allows for the delivery of radiation doses to critical organs to be reduced, resulting in a decrease in the occurrence of late adverse effects on these organs. The occurrence of side effects caused by proton therapy depends on the relative and absolute volume of organs at risk receiving specific radiation doses. Proton therapy represents a promising alternative to conventional radiotherapy due to the reduced number of complications in healthy tissues by delivering a lower radiation dose outside the tumor area.
头颈部癌症是全球第七大常见癌症，其中近半数导致死亡。头颈部癌症的常见治疗方法包括放疗和手术。对于肿瘤位于解剖学上敏感区域、必须严格限制辐射剂量的病例，质子治疗已在放疗中崭露头角。本研究旨在讨论质子治疗在各种癌症中的治疗作用，特别是头颈部肿瘤。
质子治疗可降低对关键器官的放射剂量，从而减少这些器官发生晚期不良反应的几率。质子治疗引起的副作用的发生取决于接受特定辐射剂量的危险器官的相对和绝对体积。由于在肿瘤区域外传递较低的辐射剂量，质子治疗在降低健康组织并发症的数量方面代表了常规放疗的一种有前途的替代方法。
