Do topical antiglaucoma drugs affect the cornea?

To investigate effects of beta blocker (BB; timolol or betaxolol), latanoprost, and latanoprosttimolol combination (LTC) drugs on corneal endothelial cell density (ECD) and central corneal thickness (CCT) in primary open-angle glaucoma (POAG) patients. Sixty-one patients in BB group, 64 patients in latanoprost group, 59 patients in LTC group, and 58 healthy cases in control group were included. Intraocular pressures (IOP), ECDs, and CCTs of groups were recorded at initial (pre-treatment) period, first and third years after treatment, and comparisons were done. In groups, changes of ECDs according to time were not significant ( > 0.05). In BB and control groups, changes of CCTs according to time were not significant ( > 0.05). In latanoprost and LTC groups, CCTs in both first and third years were significantly thinner than initial CCTs ( = 0.039 for latanoprost,  = 0.041 for LTC at first year;  = 0.018 for latanoprost,  = 0.032 for LTC at third year). In latanoprost and LTC groups, CCTs of patients using drugs for 1 year were similar to those of patients using drugs for 3 years ( > 0.05). In our study, uses of BB, latanoprost or LTC did not affect ECD. BB drugs had no effect on CCT. Although latanoprost and LTC appeared to reduce CCT at 3-year follow-up from the statistical point of view, this 8-10 μm difference in CCT was not clinically significant.