Kim Jae-Yun, Yim Hyeon-Woo
Graduate School, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Myung-Dong St. Mary's Eye Center, Seoul 04534, Republic of Korea.
J Clin Med. 2022 Dec 21;12(1):44. doi: 10.3390/jcm12010044.
To investigate whether prostaglandin analogue (PGA) eyedrops have a significant effect on central corneal thickness (CCT), we conducted a systematic search of literature published from 2000 to 2021. Among the studies conducted on topical PGA therapy in open-angle glaucoma or ocular hypertension patients over 18 years old, prospective studies with CCT change as an outcome were included. A single-arm meta-analysis was conducted to assess the overall effect on CCT, and subgroup analysis according to exposure time of PGA eyedrops was also performed. We counted the number of articles that reported on severe events (CCT reduction of 25 μm or more) and obtained their proportion. The methodological quality was assessed by the McHarm tool. Twenty-two reports of prospective studies were selected. The results of the single-arm meta-analysis showed very high heterogeneity. Still, in subgroup analysis, when PGA was used for more than 6 months, heterogeneity was low, and a significant decrease in CCT was observed. Severe events were reported in two reports and occurred in 3.8% to 14.8% of participants. PGA eyedrop use may cause a clinically significant CCT decrease, requiring CCT follow-up.
为研究前列腺素类似物（PGA）滴眼液是否对中央角膜厚度（CCT）有显著影响，我们对2000年至2021年发表的文献进行了系统检索。在针对18岁以上开角型青光眼或高眼压症患者进行的局部PGA治疗的研究中，纳入了以CCT变化为结局的前瞻性研究。进行单臂荟萃分析以评估对CCT的总体影响，并根据PGA滴眼液的使用时间进行亚组分析。我们统计了报告严重事件（CCT降低25μm或更多）的文章数量并得出其比例。采用McHarm工具评估方法学质量。选择了22篇前瞻性研究报告。单臂荟萃分析结果显示异质性非常高。不过，在亚组分析中，当PGA使用超过6个月时，异质性较低，且观察到CCT有显著下降。两篇报告中报告了严重事件，发生在3.8%至14.8%的参与者中。使用PGA滴眼液可能会导致临床上显著的CCT降低，需要对CCT进行随访。
