泰国氯喹抗性疟疾的体内和体外研究。
In vivo and in vitro studies of chloroquine-resistant malaria in Thailand.
作者信息
Sucharit P, Harinasuta T, Chongsuphajaisiddhi T, Tongprasroeth N, Kasemsuth R
出版信息
Ann Trop Med Parasitol. 1977 Dec;71(4):401-5. doi: 10.1080/00034983.1977.11687205.
Fourteen patients infected with falciparum malaria admitted to the Hospital for Tropical Diseases in Bangkok, Faculty of Tropical Medicine, Mahidol University, were studied. In vivo and in vitro methods were used to compare the effects of chloroquine on Plasmodium falciparum. The results showed that RI in vivo corresponded to samples containing chloroquine base 2.5-3.5 millimicromoles per ml of blood in vitro and RII in vivo corresponded to samples with chloroquine base of 4.0 millimicromoles per ml of blood.
对14名感染恶性疟原虫并入住曼谷热带病医院（玛希隆大学热带医学院）的患者进行了研究。采用体内和体外方法比较氯喹对恶性疟原虫的作用。结果显示，体内的RI相当于体外每毫升血液中含2.5 - 3.5毫微摩尔氯喹碱的样本，体内的RII相当于每毫升血液中含4.0毫微摩尔氯喹碱的样本。
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