Department of Psychology, University of California, Berkeley, CA 94720, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA.
Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA.
Semin Cell Dev Biol. 2021 Oct;118:64-72. doi: 10.1016/j.semcdb.2021.04.021. Epub 2021 May 10.
Across species, adolescence is a period of growing independence that is associated with the maturation of cognitive, social, and affective processing. Reorganization of neural circuits within the frontal cortex is believed to contribute to the emergence of adolescent changes in cognition and behavior. While puberty coincides with adolescence, relatively little is known about which aspects of frontal cortex maturation are driven by pubertal development and gonadal hormones. In this review, we highlight existing work that suggests puberty plays a role in the maturation of specific cell types in the medial prefrontal cortex (mPFC) of rodents, and highlight possible routes by which gonadal hormones influence frontal cortical circuit development.
在不同物种中，青春期是一个不断增强独立性的阶段，与认知、社会和情感处理的成熟有关。人们相信，额叶皮层内神经回路的重组有助于认知和行为出现青少年期变化。虽然青春期与青春期相吻合，但对于哪些额叶皮层成熟方面是由青春期发育和性腺激素驱动的，人们知之甚少。在这篇综述中，我们强调了现有研究工作，这些工作表明青春期在啮齿动物的内侧前额叶皮层（mPFC）中特定细胞类型的成熟中发挥作用，并强调了性腺激素影响前额皮质回路发育的可能途径。
