Department of Radiation Oncology, German Oncology Center, European University of Cyprus, Limassol, Cyprus.
Department of Radiation Oncology, German Oncology Center, European University of Cyprus, Limassol, Cyprus.
Brachytherapy. 2021 Jul-Aug;20(4):892-899. doi: 10.1016/j.brachy.2021.03.012. Epub 2021 May 10.
A growing number of patients with lung cancer are not amenable to surgery due to their age or comorbidities. For this reason, local ablative techniques have gained increasing interest recently in the management of inoperable lung tumors. High-dose-rate percutaneous interstitial brachytherapy, performed under CT-guidance, is a newer form of brachytherapy and is a highly conformal radiotherapy technique. The aim of this study was to describe this method and review the existing literature. Eight articles comprising 234 patients reported toxicity and clinical outcome. The follow-up ranged from 6 to 28 months. Diverse fractionation schemes were reported, with 20 Gy in a single fraction being the most frequently utilized. Toxicity was limited; major pneumothoraces occurred after only 8% of the interventions. Local control rates at one year ranged between 37% and 91%. In conclusion, high-dose-rate percutaneous interstitial brachytherapy is a safe, fast, and efficient treatment option for inoperable lung tumors.
越来越多的肺癌患者由于年龄或合并症而不能接受手术。出于这个原因，局部消融技术最近在不可手术的肺肿瘤的治疗中越来越受到关注。高剂量率经皮间质近距离治疗在 CT 引导下进行，是一种较新的近距离治疗形式，也是一种高度适形的放射治疗技术。本研究的目的是描述这种方法并复习现有文献。8 篇文章共 234 例患者报告了毒性和临床结果。随访时间为 6 至 28 个月。报告了不同的分割方案，其中单次 20Gy 的分割方案最常用。毒性有限，只有 8%的介入治疗后出现了严重气胸。一年后的局部控制率在 37%至 91%之间。总之，高剂量率经皮间质近距离治疗是一种安全、快速、有效的不可手术肺肿瘤治疗方法。
