Ivnik R J, Sharbrough F W, Laws E R
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905.
Mayo Clin Proc. 1988 Aug;63(8):783-93. doi: 10.1016/s0025-6196(12)62358-1.
We examined the effect of anterior temporal lobectomy on cognitive function in the treatment of intractable partial complex seizures in a sample of 142 patients. Our current results replicate previous work in this area and clearly establish the presence of differential effects on cognitive function as a consequence of the side of the operation. Learning and memory are most susceptible to impairment postoperatively, although general intellectual abilities are also affected in a small number of patients. The data are further analyzed in a manner that permits determination of the probability of cognitive alterations postoperatively for individual patients. Information is provided to assist health-care professionals in evaluating the risk-to-benefit ratio relative to cognitive abilities as they consider this treatment alternative for their patients who suffer from intractable partial complex seizures.
我们在142例患者样本中研究了前颞叶切除术对治疗顽固性部分性复杂性癫痫患者认知功能的影响。我们目前的结果重复了该领域之前的研究，并明确证实了手术侧别对认知功能存在不同影响。学习和记忆在术后最易受损，尽管少数患者的一般智力能力也受到影响。我们进一步分析了数据，以便能够确定个体患者术后发生认知改变的概率。提供这些信息是为了帮助医疗保健专业人员，在为患有顽固性部分性复杂性癫痫的患者考虑这种治疗方案时，评估相对于认知能力的风险效益比。
