Ivnik R J, Sharbrough F W, Laws E R
J Clin Psychol. 1987 Jan;43(1):128-37. doi: 10.1002/1097-4679(198701)43:1<128::aid-jclp2270430121>3.0.co;2-q.
Sixty-three patients with intractable partial complex epilepsy were treated by anterior temporal lobectomy for seizure control. Psychometric studies before and after operation documented cognitive function and evaluated the effects of operation on cognition. The mean follow-up period was 7.7 months. Sixty-two of 63 patients had improved seizure control; 49 (78%) were seizure free. Operation had different effects on cognitive abilities in those with right vs. left temporal lobe excisions. Although both groups maintained summary IQ scores in the average range, after operation the left temporal group was less efficient on language-dependent cognitive tasks, particularly those that involved complex learning and memory. In contrast, persons who had right temporal ablations were either unchanged or slightly better cognitively after operation. Future research and clinical evaluations should focus on the components of the learning and memory processes when the ramifications of temporal lobe ablations on cognitive function are studied.
63例顽固性部分复杂性癫痫患者接受了前颞叶切除术以控制癫痫发作。术前和术后的心理测量研究记录了认知功能，并评估了手术对认知的影响。平均随访期为7.7个月。63例患者中有62例癫痫发作得到改善；49例（78%）无癫痫发作。手术对右侧与左侧颞叶切除患者的认知能力有不同影响。尽管两组的总智商得分均维持在平均水平，但术后左侧颞叶组在依赖语言的认知任务上效率较低，尤其是那些涉及复杂学习和记忆的任务。相比之下，接受右侧颞叶切除术的患者术后认知能力要么没有变化，要么略有改善。在研究颞叶切除术对认知功能的影响时，未来的研究和临床评估应关注学习和记忆过程的组成部分。
