NFL 与 AD 患者血浆中的 TNF-R1 强烈相关，但与认知能力下降无关。
NFL strongly correlates with TNF-R1 in the plasma of AD patients, but not with cognitive decline.
机构信息
Laboratoire de Biochimie Protéomique, INM, Université de Montpellier, INSERM, CHU Montpellier, IRMB, Montpellier, France.
Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
出版信息
Sci Rep. 2021 May 13;11(1):10283. doi: 10.1038/s41598-021-89749-5.
Peripheral inflammation mechanisms involved in Alzheimer's disease (AD) have yet to be accurately characterized and the identification of blood biomarker profiles could help predict cognitive decline and optimize patient care. Blood biomarkers described to date have failed to provide a consensus signature, which is mainly due to the heterogeneity of the methods used or the cohort. The present work aims to describe the potential informativity of peripheral inflammation in AD, focusing in particular on the potential association between the level of plasma neurofilament light (NFL), peripheral inflammation (by quantifying IL-1β, IL-6, TNFα, CCL5, TNF-R1, sIL-6R, TIMP-1, IL-8 in blood) and cognitive decline (assessed by the MMSE and ADAScog scales) through a 2-year follow-up of 40 AD patients from the Cytocogma cohort (CHU Poitiers, Pr M. Paccalin). Our results show for the first time a strong correlation between plasma NFL and TNF-R1 at each time of follow-up (baseline, 12 and 24 months), thus opening an interesting perspective for the prognosis of AD patients.
外周炎症机制在阿尔茨海默病（AD）中的作用尚未得到准确描述，而识别血液生物标志物谱可能有助于预测认知能力下降并优化患者护理。迄今为止，描述的血液生物标志物未能提供共识特征，这主要是由于使用的方法或队列的异质性所致。本研究旨在描述外周炎症在 AD 中的潜在信息性，特别是重点关注血浆神经丝轻链（NFL）水平与外周炎症（通过定量检测血液中的 IL-1β、IL-6、TNFα、CCL5、TNF-R1、sIL-6R、TIMP-1、IL-8）与认知能力下降（通过 MMSE 和 ADAScog 量表评估）之间的潜在关联，该研究对 Cytocogma 队列（普瓦捷大学附属医院，Pr M. Paccalin）的 40 名 AD 患者进行了为期 2 年的随访。我们的研究结果首次表明，在每次随访（基线、12 个月和 24 个月）时，血浆 NFL 与 TNF-R1 之间存在强烈相关性，这为 AD 患者的预后开辟了一个有趣的视角。
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