Laboratory of Research in Clinical Nutrition and Sports (Labince), Faculty of Nutrition, Federal University of Goiás, Goiânia, Brazil.
Clinical Nutrition, Geneva University Hospital, Geneva, Switzerland.
Eur J Clin Nutr. 2022 Feb;76(2):206-211. doi: 10.1038/s41430-021-00931-4. Epub 2021 May 13.
Cancer and its treatments often lead to sarcopenia and fatigue. However, whether these factors are associated remains unproven.
To evaluate whether the risk of sarcopenia predicts the presence of fatigue.
A cross-sectional study was completed and included 198 cancer patients of both sexes, undergoing in- and outpatient treatment. The Strength, Assistance for walking, Rise from a chair, Climb stairs, and Falls (SARC-F) and the Functional Assessment of Cancer Therapy Fatigue (FACT-F) were used to assess the risk of sarcopenia and the presence of fatigue, respectively. The cut-off values used to identify the risk of sarcopenia and the severity of fatigue scale were SARC-F ≥ 4 and Fatigue <34, respectively. Logistic regression analysis was performed to evaluate the association between SARC-F and the FACT-F.
Out of 198 patients, 35% were at risk of sarcopenia and of these 87% had fatigue. Patients at risk of sarcopenia had lower scores in the FACT-F subscales, lower handgrip strength, lower performance status, were mostly hospitalized and were sedentary. Logistic regression analysis revealed that patients with SARC-F < 4 had a lower risk of fatigue in both models, crude (OR: 0.83; CI 95% [0.79-0.88], p < 0.0001) as well as adjusted for age, gender, BMI, physical activity, current use of alcoholic beverages, smoking, performance status, cancer type, clinical setting and use of supplements (OR: 0.87; CI 95% [0.81-0.92], p < 0.0001).
In patients with cancer, 35% presented risk of sarcopenia and of these 87% had fatigue. In addition, the absence of sarcopenia was considered protective against fatigue.
癌症及其治疗常导致肌肉减少症和疲劳。然而，这些因素是否相关仍未得到证实。
评估肌肉减少症的风险是否预示疲劳的发生。
完成了一项横断面研究，共纳入 198 名男女癌症患者，接受门诊和住院治疗。使用力量、助行能力、椅子起身能力、爬楼梯能力和跌倒（SARC-F）和癌症治疗疲劳功能评估（FACT-F）分别评估肌肉减少症的风险和疲劳的发生。用于识别肌肉减少症风险和疲劳严重程度的截断值分别为 SARC-F≥4 和疲劳<34。采用 logistic 回归分析评估 SARC-F 与 FACT-F 之间的关联。
在 198 名患者中，35%有肌肉减少症风险，其中 87%有疲劳。有肌肉减少症风险的患者在 FACT-F 各亚量表中的得分较低，握力较低，体能状态较差，大多数住院且久坐。logistic 回归分析显示，在两个模型中，SARC-F<4 的患者发生疲劳的风险均较低，未校正模型（OR：0.83；95%CI[0.79-0.88]，p<0.0001）和校正模型（OR：0.87；95%CI[0.81-0.92]，p<0.0001）。
在癌症患者中，35%有肌肉减少症风险，其中 87%有疲劳。此外，没有肌肉减少症被认为是对疲劳的一种保护。
