肌肉减少症作为癌症住院患者营养状况和合并症的预测指标：一项横断面研究。

Sarcopenia as a predictor of nutritional status and comorbidities in hospitalized patients with cancer: A cross-sectional study.

作者信息

Borges Thais C, Gomes Tatyanne L N, Pimentel Gustavo D

机构信息

Laboratory of Research in Clinical Nutrition and Sports (Labince), Faculty of Nutrition, Federal University of Goiás, Goiânia, Brazil.

出版信息

Nutrition. 2020 May;73:110703. doi: 10.1016/j.nut.2019.110703. Epub 2019 Dec 14.

DOI:10.1016/j.nut.2019.110703

PMID:32007693

Abstract

OBJECTIVES

Sarcopenia promotes worsening of nutritional status and an increase in comorbidities. Likewise, use of validated instruments to assess nutritional and comorbidity factors are warranted. Thus, the objectives were to assess the prevalence of risk for sarcopenia and to determine whether there is an association between sarcopenia and nutritional status and comorbidities in hospitalized patients with cancer.

METHODS

This was a cross-sectional study with 77 patients with different types of cancer. Both men and women were enrolled. The risk for sarcopenia was assessed by the Strength, Assistance With Walking, Rise From a Chair, Climb Stairs, and Falls (SARC-F) questionnaire. Patients were divided into two groups: risk for sarcopenia (SARC-F score ≥4) and no risk for sarcopenia (SARC-F score <4). The presence of comorbidities and nutritional risks were analyzed using Charlson Comorbidity Index (CCI) and Nutrition Risk Screening 2002 (NRS-2002), respectively. Logistic and multiple regression analyses were used to verify the association and predictive factors of SARC-F.

RESULTS

Of the 77 patients, 40.2% (n = 31; 63.48 ± 10.59 y of age) were classified as having a risk for sarcopenia and 59.7% (n = 46; 51.20 ± 12.81 y of age) without risk. We found an association between the risk for sarcopenia and CCI and NRS-2002 in crude model and after adjustment for age. Additionally, SARC-F is a good predictor of the increase of CCI (β = 0.357, R² = 0.29, P = 0.003) and NRS-2002 (β = 0.519, R² = 0.49, P < 0.001).

CONCLUSION

In the present study, ∼40% of patients with cancer had a risk for sarcopenia and a greater prediction for nutritional risk (49%) and comorbidities (29%).

摘要

目的

肌肉减少症会促使营养状况恶化并增加合并症。同样，使用经过验证的工具来评估营养和合并症因素是必要的。因此，本研究的目的是评估癌症住院患者中肌肉减少症的风险患病率，并确定肌肉减少症与营养状况及合并症之间是否存在关联。

方法

这是一项针对77例不同类型癌症患者的横断面研究。纳入了男性和女性患者。通过力量、行走辅助、从椅子上起身、爬楼梯和跌倒（SARC-F）问卷评估肌肉减少症的风险。患者被分为两组：肌肉减少症风险组（SARC-F评分≥4）和无肌肉减少症风险组（SARC-F评分<4）。分别使用Charlson合并症指数（CCI）和营养风险筛查2002（NRS-2002）分析合并症和营养风险的存在情况。采用逻辑回归和多元回归分析来验证SARC-F的关联和预测因素。

结果

77例患者中，40.2%（n = 31；年龄63.48±10.59岁）被归类为有肌肉减少症风险，59.7%（n = 46；年龄51.20±12.81岁）无风险。在未调整年龄的原始模型以及调整年龄后，我们发现肌肉减少症风险与CCI和NRS-2002之间存在关联。此外，SARC-F是CCI升高（β = 0.357，R² = 0.29，P = 0.003）和NRS-2002升高（β = 0.519，R² = 0.49，P < 0.001）的良好预测指标。