School of Medicine, University of California, Irvine, CA, USA.
Osteoporosis Center of Armenia, Yerevan, Armenia.
Eur J Clin Nutr. 2022 Feb;76(2):220-226. doi: 10.1038/s41430-021-00934-1. Epub 2021 May 13.
Vitamin D plays a critical role in skeletal development and maintenance, thus sufficiency is an important goal for public health programs. Given the absence of foods fortified in vitamin D in Armenia, we hypothesized that vitamin D insufficiency would be widespread.
We conducted a random modified cluster model survey of vitamin D status of women in the country. We measured 25-hydroxyvitamin D [25(OH)D] by liquid chromatography mass spectrometry in dried blood spot samples and utilized a questionnaire to assess lifestyle factors.
In summer, we sampled 1206 participants from 40 communities in Armenia. Mean 25-OH D level among women aged 18-24 was 20 ± 8 ng/mL; aged 25-64 was 21 ± 7 ng/mL; and >65 was 18 ± 8 ng/mL. The country-wide mean of the entire female population was 20 ± 8 ng/mL. A majority (>54%) had 25-OH D levels <20 ng/mL with nearly 13% having 25-OH D levels <12 ng/mL. Participants who reported calcium, vitamin D, or multivitamin supplementation had higher levels of 25-OH D (p values 0.004, 0.0002, and 0.03 respectively) as did pre- vs. postmenopausal women (p = 0.01), pregnant vs. nonpregnant women (p = <0.0001), and women who had experienced a sunburn in the past year (p = 0.004).
In Armenia, there is a high prevalence of vitamin D insufficiency. This information provides data that can be used to inform public health directives to address this pervasive threat to optimal health.
维生素 D 在骨骼发育和维持中起着关键作用，因此充足的维生素 D 是公共卫生计划的重要目标。鉴于亚美尼亚没有强化维生素 D 的食物，我们假设维生素 D 不足会很普遍。
我们对该国的女性进行了一项随机的改良聚类模型维生素 D 状况调查。我们通过液相色谱质谱法在干血斑样本中测量 25-羟维生素 D [25(OH)D]，并利用问卷评估生活方式因素。
在夏季，我们从亚美尼亚的 40 个社区中抽取了 1206 名参与者。18-24 岁女性的平均 25-OHD 水平为 20±8ng/ml；25-64 岁女性为 21±7ng/ml；>65 岁女性为 18±8ng/ml。整个女性群体的全国平均水平为 20±8ng/ml。大多数（>54%）女性的 25-OHD 水平<20ng/ml，近 13%的女性的 25-OHD 水平<12ng/ml。报告钙、维生素 D 或多种维生素补充剂的参与者 25-OHD 水平较高（p 值分别为 0.004、0.0002 和 0.03），绝经前与绝经后妇女相比（p=0.01）、孕妇与非孕妇相比（p<0.0001）以及过去一年有晒伤史的妇女相比（p=0.004）。
在亚美尼亚，维生素 D 不足的患病率很高。这些信息提供了数据，可以用来为解决这一普遍存在的健康威胁的公共卫生指令提供信息。
