• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

维生素D减少早期妊娠丢失：血清1,25-(OH)D调节与流产风险分析

Reducing early pregnancy loss with vitamin D: an analysis of serum 1,25-(OH)D modulation and miscarriage risk.

作者信息

Zhao Qian, Wang Liangying, Xiang Hongqin, Qiu Luling

机构信息

Department of Obstetrics and Gynecology in Hangzhou First People's Hospital Tonglu Hospital in Zhejiang Province, Hangzhou, No. 899 Meilin Road, Chengnan Street, Tonglu, Hangzhou 311500, Zhejiang Province, China.

出版信息

J Clin Biochem Nutr. 2025 Mar;76(2):164-178. doi: 10.3164/jcbn.24-147. Epub 2024 Oct 29.

DOI:10.3164/jcbn.24-147
PMID:40151409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11936736/
Abstract

This case-control study of 124 early-pregnant women found that daily supplementation with 400 IU of vitamin D significantly increased serum 1,25-(OH)D levels and was associated with a lower incidence of threatened miscarriage. The study suggests that vitamin D supplementation could reduce the risk of early miscarriage and improve pregnancy outcomes by modulating immune responses and hormonal stability.

摘要

这项针对124名早孕女性的病例对照研究发现，每日补充400国际单位的维生素D可显著提高血清1,25-(OH)D水平，并与先兆流产发生率较低相关。该研究表明，补充维生素D可通过调节免疫反应和激素稳定性来降低早期流产风险并改善妊娠结局。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6efe/11936736/ea2c229d90f3/jcbn24-147f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6efe/11936736/559141d476e3/jcbn24-147f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6efe/11936736/03484b964db0/jcbn24-147f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6efe/11936736/9adc834a287f/jcbn24-147f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6efe/11936736/649e34c9f1ea/jcbn24-147f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6efe/11936736/93f97fbc5881/jcbn24-147f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6efe/11936736/972dae1fab85/jcbn24-147f06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6efe/11936736/65786c03ddf9/jcbn24-147f07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6efe/11936736/beab79b2b236/jcbn24-147f08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6efe/11936736/6d10a1d8803a/jcbn24-147f09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6efe/11936736/84150867068d/jcbn24-147f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6efe/11936736/ea2c229d90f3/jcbn24-147f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6efe/11936736/559141d476e3/jcbn24-147f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6efe/11936736/03484b964db0/jcbn24-147f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6efe/11936736/9adc834a287f/jcbn24-147f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6efe/11936736/649e34c9f1ea/jcbn24-147f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6efe/11936736/93f97fbc5881/jcbn24-147f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6efe/11936736/972dae1fab85/jcbn24-147f06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6efe/11936736/65786c03ddf9/jcbn24-147f07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6efe/11936736/beab79b2b236/jcbn24-147f08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6efe/11936736/6d10a1d8803a/jcbn24-147f09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6efe/11936736/84150867068d/jcbn24-147f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6efe/11936736/ea2c229d90f3/jcbn24-147f11.jpg

相似文献

1
Reducing early pregnancy loss with vitamin D: an analysis of serum 1,25-(OH)D modulation and miscarriage risk.维生素D减少早期妊娠丢失：血清1,25-(OH)D调节与流产风险分析
J Clin Biochem Nutr. 2025 Mar;76(2):164-178. doi: 10.3164/jcbn.24-147. Epub 2024 Oct 29.
2
Effect of vitamin D3 supplementation in pregnancy on risk of pre-eclampsia - Randomized controlled trial.孕期补充维生素 D3 对子痫前期发病风险的影响——随机对照试验
Clin Nutr. 2019 Apr;38(2):557-563. doi: 10.1016/j.clnu.2018.02.023. Epub 2018 Mar 2.
3
Different vitamin D supplementation strategies impact serum vitamin D concentrations and the mRNA expression of genes related to vitamin D metabolism, mitochondria respiration, redox balance, and immune system in weanling piglets.不同的维生素D补充策略会影响断奶仔猪的血清维生素D浓度以及与维生素D代谢、线粒体呼吸、氧化还原平衡和免疫系统相关基因的mRNA表达。
J Anim Sci. 2025 Jan 4;103. doi: 10.1093/jas/skaf024.
4
Pharmacokinetics of high-dose weekly oral vitamin D3 supplementation during the third trimester of pregnancy in Dhaka, Bangladesh.孟加拉国达卡妊娠晚期高剂量每周口服维生素 D3 补充的药代动力学。
Nutrients. 2013 Mar 12;5(3):788-810. doi: 10.3390/nu5030788.
5
Vitamin D3 supplementation during pregnancy and lactation for women living with HIV in Tanzania: A randomized controlled trial.坦桑尼亚艾滋病毒感染者孕妇和哺乳期妇女补充维生素 D3：一项随机对照试验。
PLoS Med. 2022 Apr 15;19(4):e1003973. doi: 10.1371/journal.pmed.1003973. eCollection 2022 Apr.
6
Severe vitamin D deficiency among pregnant women and their newborns in Turkey.土耳其孕妇及其新生儿中严重维生素D缺乏的情况。
J Matern Fetal Neonatal Med. 2015 Mar;28(5):548-51. doi: 10.3109/14767058.2014.924103. Epub 2014 May 30.
7
Randomized trial of two doses of vitamin D3 in preterm infants <32 weeks: Dose impact on achieving desired serum 25(OH)D3 in a NICU population.32周以下早产儿两种剂量维生素D3的随机试验：剂量对新生儿重症监护病房人群中达到理想血清25(OH)D3水平的影响
PLoS One. 2017 Oct 10;12(10):e0185950. doi: 10.1371/journal.pone.0185950. eCollection 2017.
8
Vitamin D Status Increases During Pregnancy and in Response to Vitamin D Supplementation in Rural Gambian Women.维生素 D 状态在孕期增加，并对冈比亚农村妇女的维生素 D 补充有反应。
J Nutr. 2020 Mar 1;150(3):492-504. doi: 10.1093/jn/nxz290.
9
Vitamin D Deficiency in Mexican Pregnant Women: Is Supplementation with ≤400 IU/day Enough?墨西哥孕妇维生素 D 缺乏：每天补充 ≤400IU 是否足够？
Nutrients. 2020 Aug 20;12(9):2517. doi: 10.3390/nu12092517.
10
Effect of supplementation of vitamin D or vitamin D on serum concentrations of free and total 25-hydroxyvitamin D and the expression of genes involved in immune function in peripheral blood mononuclear cells of weaned pigs.维生素 D 或维生素 D 补充对断奶仔猪外周血单个核细胞中游离和总 25-羟维生素 D 血清浓度及免疫功能相关基因表达的影响。
Arch Anim Nutr. 2023 Jun;77(3):228-244. doi: 10.1080/1745039X.2023.2219176. Epub 2023 Jun 19.

本文引用的文献

1
Depression during pregnancy and associated factors among women in Ethiopia: a systematic review and meta-analysis.孕期抑郁及相关因素：埃塞俄比亚妇女的系统评价和荟萃分析。
BMC Pregnancy Childbirth. 2024 Mar 26;24(1):220. doi: 10.1186/s12884-024-06409-y.
2
The Influence of Vitamin D on Pregnancy and Outcomes: Current Knowledge and Future Perspectives.维生素 D 对妊娠结局的影响：现有知识和未来展望。
Gynecol Obstet Invest. 2024;89(4):261-266. doi: 10.1159/000538085. Epub 2024 Mar 8.
3
Perceptions and experiences of intravenous iron treatment for anaemia in pregnancy in Malawi: a formative qualitative study.
马拉维孕期贫血静脉铁剂治疗的认知与体验：一项质性形成性研究
Gates Open Res. 2024 Mar 8;6:66. doi: 10.12688/gatesopenres.13631.2. eCollection 2022.
4
The Effects of Vegan Diet on Fetus and Maternal Health: A Review.纯素饮食对胎儿及母体健康的影响：综述
Cureus. 2023 Oct 30;15(10):e47971. doi: 10.7759/cureus.47971. eCollection 2023 Oct.
5
Effects of vitamin D supplementation on ovulation and pregnancy in women with polycystic ovary syndrome: a systematic review and meta-analysis.维生素 D 补充对多囊卵巢综合征妇女排卵和妊娠的影响：系统评价和荟萃分析。
Front Endocrinol (Lausanne). 2023 Aug 1;14:1148556. doi: 10.3389/fendo.2023.1148556. eCollection 2023.
6
Vitamin D Therapy in Adults With CKD: A Systematic Review and Meta-analysis.成人慢性肾脏病患者的维生素D治疗：一项系统评价与荟萃分析
Am J Kidney Dis. 2023 Nov;82(5):543-558. doi: 10.1053/j.ajkd.2023.04.003. Epub 2023 Jun 24.
7
Reply to Pluta, R. Comment on "Minich et al. Is Melatonin the "Next Vitamin D"?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements. 2022, , 3934".对普鲁塔的回复，R. 关于《米尼克等人。褪黑素会成为“下一个维生素D”吗？新兴科学、临床应用、安全性及膳食补充剂综述。2022年，，3934》的评论。
Nutrients. 2023 Mar 21;15(6):1507. doi: 10.3390/nu15061507.
8
Contribution of semen to early embryo development: fertilization and beyond.精液对早期胚胎发育的贡献：受精及以后。
Hum Reprod Update. 2023 Jul 5;29(4):395-433. doi: 10.1093/humupd/dmad006.
9
Calcifediol: a review of its pharmacological characteristics and clinical use in correcting vitamin D deficiency.骨化二醇：纠正维生素 D 缺乏症的药理学特征和临床应用评价。
Eur J Nutr. 2023 Jun;62(4):1579-1597. doi: 10.1007/s00394-023-03103-1. Epub 2023 Mar 2.
10
Pregnancy complications and later life women's health.妊娠并发症与女性后期生命健康。
Acta Obstet Gynecol Scand. 2023 May;102(5):523-531. doi: 10.1111/aogs.14523. Epub 2023 Feb 17.