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视觉剥夺会延缓小鼠视网膜神经节细胞树突野和感受野的成熟。

Visual Deprivation Retards the Maturation of Dendritic Fields and Receptive Fields of Mouse Retinal Ganglion Cells.

作者信息

Chen Hui, Xu Hong-Ping, Wang Ping, Tian Ning

机构信息

Department of Ophthalmology and Visual Science, University of Utah School of Medicine, Salt Lake City, UT, United States.

Department of Neurobiology, Yale University School of Medicine, New Haven, CT, United States.

出版信息

Front Cell Neurosci. 2021 Apr 27;15:640421. doi: 10.3389/fncel.2021.640421. eCollection 2021.

DOI:10.3389/fncel.2021.640421
PMID:33986645
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8111083/
Abstract

It was well documented that both the size of the dendritic field and receptive field of retinal ganglion cells (RGCs) are developmentally regulated in the mammalian retina, and visual stimulation is required for the maturation of the dendritic and receptive fields of mouse RGCs. However, it is not clear whether the developmental changes of the RGC receptive field correlate with the dendritic field and whether visual stimulation regulates the maturation of the dendritic field and receptive field of RGCs in a correlated manner. The present work demonstrated that both the dendritic and receptive fields of RGCs continuously develop after eye opening. However, the correlation between the developmental changes in the receptive field size and the dendritic field varies among different RGC types. These results suggest a continuous change of synaptic converging of RGC synaptic inputs in an RGC type-dependent manner. Besides, light deprivation impairs both the development of dendritic and receptive fields.

摘要

有充分的文献记载，在哺乳动物视网膜中，视网膜神经节细胞（RGCs）的树突野和感受野大小在发育过程中均受到调控，并且视觉刺激是小鼠RGCs树突和感受野成熟所必需的。然而，尚不清楚RGC感受野的发育变化是否与树突野相关，以及视觉刺激是否以相关方式调节RGCs树突野和感受野的成熟。目前的研究表明，RGCs的树突和感受野在睁眼后持续发育。然而，感受野大小的发育变化与树突野之间的相关性在不同类型的RGCs中有所不同。这些结果表明，RGC突触输入的突触汇聚以RGC类型依赖的方式持续变化。此外，剥夺光照会损害树突和感受野的发育。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a53/8111083/9cc1d0719d00/fncel-15-640421-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a53/8111083/6fabc66775cc/fncel-15-640421-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a53/8111083/64e09a2bdc52/fncel-15-640421-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a53/8111083/3c0eb4453d5f/fncel-15-640421-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a53/8111083/602a3e06c654/fncel-15-640421-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a53/8111083/9cc1d0719d00/fncel-15-640421-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a53/8111083/6fabc66775cc/fncel-15-640421-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a53/8111083/64e09a2bdc52/fncel-15-640421-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a53/8111083/3c0eb4453d5f/fncel-15-640421-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a53/8111083/602a3e06c654/fncel-15-640421-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a53/8111083/9cc1d0719d00/fncel-15-640421-g005.jpg

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