Department of Pharmacology, University of Oxford, Oxford, United Kingdom.
Pharmaceutical Sciences Department, College of Pharmacy, King Saud Bin Abdul-Aziz University for Health Sciences, Riyadh, Saudi Arabia.
Front Immunol. 2021 Apr 27;12:656965. doi: 10.3389/fimmu.2021.656965. eCollection 2021.
The role of endolysosomal Ca signalling in immunity has been a subject of increasing interest in recent years. Here, we discuss evolving knowledge relating to the contribution of endolysosomal Ca channels that include TPCs, TRPMLs, and P2X4R in physiological processes related to innate and adaptive immunity-including phagocytosis, inflammation, cytokine/chemokine release, dendritic, natural killer, and T cell activation and migration-and we underscore the paucity of clinical studies in this field. Emerging biomedical and translational data have led to important new insights into the critical roles of these channels in immune cell function and the regulation of innate and adaptive immune responses. The evolving immunological significance of endolysosomal Ca signalling warrants further investigations to better characterize the roles of these channels in immunity in order to expand our knowledge about the pathology of inflammatory and autoimmune diseases and develop endolysosomal Ca channels as viable biomarkers and therapeutic and preventive targets for remodelling the immune response.
近年来，内体溶酶体 Ca 信号在免疫中的作用一直是人们日益关注的课题。在这里，我们讨论了与内体溶酶体 Ca 通道（包括 TPCs、TRPMLs 和 P2X4R）在与先天和适应性免疫相关的生理过程中的贡献有关的不断发展的知识，包括吞噬作用、炎症、细胞因子/趋化因子释放、树突状细胞、自然杀伤细胞和 T 细胞的激活和迁移，我们强调了这一领域临床研究的缺乏。新兴的生物医学和转化数据为这些通道在免疫细胞功能和先天和适应性免疫反应的调节中的关键作用提供了重要的新见解。内体溶酶体 Ca 信号的不断发展的免疫学意义需要进一步的研究来更好地描述这些通道在免疫中的作用，以便扩展我们对炎症性和自身免疫性疾病病理学的认识，并将内体溶酶体 Ca 通道作为可行的生物标志物和治疗及预防靶点，以重塑免疫反应。
