Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy.
Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131 Naples, Italy.
Cells. 2024 Jun 21;13(13):1079. doi: 10.3390/cells13131079.
IBD is an uncontrolled inflammatory condition of the gastrointestinal tract, which mainly manifests in two forms: ulcerative colitis (UC) and Crohn's disease (CD). The pathogenesis of IBD appears to be associated with an abnormal response of innate and adaptive immune cells. Innate immunity cells, such as macrophages, mast cells, and granulocytes, can produce proinflammatory (e.g., TNF-α) and oxidative stress (ROS) mediators promoting intestinal damage, and their abnormal responses can induce an imbalance in adaptive immunity, leading to the production of inflammatory cytokines that increase innate immune damage, abate intestinal barrier functions, and aggravate inflammation. Considering that Ca signalling plays a key role in a plethora of cellular functions, this review has the purpose of deepening the potential Ca involvement in IBD pathogenesis.
IBD 是一种胃肠道的失控性炎症性疾病，主要有两种表现形式：溃疡性结肠炎（UC）和克罗恩病（CD）。IBD 的发病机制似乎与先天和适应性免疫细胞的异常反应有关。先天免疫细胞，如巨噬细胞、肥大细胞和粒细胞，可产生促炎（如 TNF-α）和氧化应激（ROS）介质，促进肠道损伤，其异常反应可诱导适应性免疫失衡，导致炎症细胞因子的产生增加，先天免疫损伤加重，肠道屏障功能减弱，炎症加重。鉴于钙信号在众多细胞功能中发挥着关键作用，本综述旨在深入探讨钙在 IBD 发病机制中的潜在作用。
