Davis K L, Berger P A, Hollister L E, Defraites E
Arch Gen Psychiatry. 1978 Jan;35(1):119-22. doi: 10.1001/archpsyc.1978.01770250121012.
Seven men and one woman with primary affective disorder, mania, were given a slow intravenous infusion of physostigmine salicylate. In six patients, mood and thought content changed from mania toward depression as evaluated by either a visual analog mood scale or the Pettersen scale. Two other patients, who were the only predominantly irritable manics in the study, demonstrated little change in their hostility, although one became somewhat depressed. These findings are consistent with earlier reports of suppression of manic symptoms after physostigmine infusion in some but not all patients with mania. The pharmacologic mechanism of physostigmine reversal of manic symptoms may be the direct result of increased cholinergic activity or a result of the effect of increased cholinergic activity on other brain neurotransmitters.
七名患有原发性情感障碍（躁狂症）的男性和一名女性接受了水杨酸毒扁豆碱的缓慢静脉输注。通过视觉模拟情绪量表或彼得森量表评估，六名患者的情绪和思维内容从躁狂转向抑郁。另外两名患者是该研究中仅有的以易激惹为主的躁狂症患者，他们的敌意几乎没有变化，尽管其中一人变得有些抑郁。这些发现与早期关于在部分但并非所有躁狂症患者中输注毒扁豆碱后躁狂症状受到抑制的报道一致。毒扁豆碱逆转躁狂症状的药理机制可能是胆碱能活性增加的直接结果，或者是胆碱能活性增加对其他脑内神经递质产生作用的结果。
