Shopsin B, Janowsky D, Davis J, Gershon S
Neuropsychobiology. 1975;1(3):180-7. doi: 10.1159/000117490.
The authors have administered physostigmine intravenously to three hospitalized manic patients on a double-blind basis. All three individuals showed clinical change both during and after the physostigmine period, which can be clearly delineated into three distinct phases. The behavioral modifications occurring during the physostigmine run did not qualitatively alter the underlying mania. The authors focus on 'rebound' phenomena, or post-physostigmine changes, as a possible clinical index with which chemically to characterize the initial state of amine imbalance responsible for a given affective illness. The data are considered consistent with an adrenergic-dopaminergic-cholinergic balance hypothesis of affective disorders, and may provide a relevant link in understanding the interface or crossover between manic and schizo-affective illness.
作者对三名住院躁狂患者进行了双盲静脉注射毒扁豆碱治疗。所有三名患者在毒扁豆碱治疗期间及之后均出现了临床变化，这些变化可清晰地分为三个不同阶段。在毒扁豆碱治疗过程中出现的行为改变并未从质上改变潜在的躁狂症状。作者将重点放在“反弹”现象，即毒扁豆碱治疗后的变化上，将其作为一种可能的临床指标，用以从化学角度表征导致特定情感疾病的胺失衡初始状态。这些数据被认为与情感障碍的肾上腺素能 - 多巴胺能 - 胆碱能平衡假说相符，并且可能为理解躁狂症与分裂情感性疾病之间的界面或交叉提供相关联系。
