Edelstein P, Schultz J R, Hirschowitz J, Kanter D R, Garver D L
Am J Psychiatry. 1981 Aug;138(8):1078-81. doi: 10.1176/ajp.138.8.1078.
Conflicting reports concerning cholinomimetic-induced reduction of schizophrenic symptoms prompted the authors to study such changes in schizophrenic symptoms following physostigmine infusions in subgroups of patients with schizophrenic-like illness. These subgroups were defined by the presence or absence of antipsychotic response during a 2-week trial of lithium alone after physostigmine infusion. Patients who showed significant but temporary improvement in their thinking disturbance on serial Brief Psychiatric Rating Scale scores following physostigmine infusion subsequently responded to lithium; patients who failed to improve following physostigmine also failed to respond to lithium. The authors suggest that some schizophrenic-like illnesses may be biologically similar to mania both with respect to physostigmine and lithium-induced changes in symptomatology.
关于拟胆碱药引起精神分裂症症状减轻的报道相互矛盾，促使作者对类精神分裂症样疾病患者亚组在注射毒扁豆碱后精神分裂症症状的此类变化进行研究。这些亚组是根据在毒扁豆碱注射后单独使用锂进行的为期2周的试验期间是否有抗精神病反应来定义的。在毒扁豆碱注射后，连续简易精神状态评定量表评分显示思维障碍有显著但暂时改善的患者随后对锂有反应；毒扁豆碱注射后未改善的患者对锂也无反应。作者认为，就毒扁豆碱和锂引起的症状变化而言，一些类精神分裂症样疾病在生物学上可能与躁狂症相似。
