Fahlbusch B, Zschiesche W, Schumann I, Tonew E
Arch Immunol Ther Exp (Warsz). 1977;25(5):701-5.
Serum obtained 16 hr after p.o. application of tilorone [2, 7-bis/2-diethylaminoethoxy/-fluoren-9-one dihydrochloride] to ABD2F1 mice demonstrated both interferon and migration inhibitory (MIF) activity. Kinetic studies showed a close correspondence between interferon and MIF serum levels. The physiochemical characteristics of tilorone-induced MIF (heat and pH lability, molecular size) are compared with those of MIF generated in in vitro lymphocyte cultures. The findings are discussed in relation to production of lymphocytogenic lymphokines.
给ABD2F1小鼠口服泰洛龙[2,7-双/2-二乙氨基乙氧基/-芴-9-酮二盐酸盐]16小时后获得的血清显示出干扰素和迁移抑制（MIF）活性。动力学研究表明，干扰素和MIF血清水平之间密切相关。将泰洛龙诱导的MIF的理化特性（热稳定性和pH稳定性、分子大小）与体外淋巴细胞培养中产生的MIF的理化特性进行了比较。结合淋巴细胞生成性淋巴因子的产生对这些发现进行了讨论。
